推荐产品
表单
powder
质量水平
储存条件
(Keep container tightly closed in a dry and well-ventilated place. Light sensitive.)
颜色
white to faint yellow
抗生素抗菌谱
Gram-negative bacteria
Gram-positive bacteria
mycobacteria
parasites
作用机制
enzyme | inhibits
储存温度
2-8°C
SMILES字符串
COc1cnc(NS(=O)(=O)c2ccc(N)cc2)nc1
InChI
1S/C11H12N4O3S/c1-18-9-6-13-11(14-7-9)15-19(16,17)10-4-2-8(12)3-5-10/h2-7H,12H2,1H3,(H,13,14,15)
InChI key
GPTONYMQFTZPKC-UHFFFAOYSA-N
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相关类别
一般描述
Chemical structure: sulfonamide
应用
Sulfameter is a sulfonamide antibiotic used as a leprostatic agent and to treat urinary tract infections. It has been investigated as a potential therapy for chloroquine-resistant malaria during pregnancy.
生化/生理作用
Sulfameter is a sulfonamide antibiotic. Sulfonamides block the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfonamides are competitive inhibitors of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. Sulfameter is a dihydrofolate reductase (DHFR) inhibitor. Sulfonamides are active against Gram positive bacteria and Gram negative bacteria. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.
其他说明
Keep container tightly closed in a dry and well-ventilated place. Light sensitive.
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
M Forland et al.
Diabetes care, 8(5), 499-506 (1985-09-01)
Forty-five women with diabetes mellitus and urinary tract infections have been followed an average of 34 mo on treatment protocols based on localization of infection as determined by the presence or absence of antibody-coated bacteria (ACB). Treatment was usually, but
Treatment of Chloroquine-Resistant Malaria During Pregnancy
Elliott K. Main, Denise M. Main, et al.
Journal of the American Medical Association, 249, 3207-3209 (1983)
Identification of polymorphs of sulfamethoxydiazine by optical and morphological methods.
T Yokoyama et al.
Chemical & pharmaceutical bulletin, 26(4), 1044-1048 (1978-04-01)
The effect of gastro-intestinal filling on the absorption of sulfametoxydiazine.
S Kaumeier et al.
International journal of clinical pharmacology and biopharmacy, 17(10), 412-415 (1979-10-01)
I U Asuzu et al.
Biochemical medicine and metabolic biology, 39(2), 158-167 (1988-04-01)
The interactions of aflatoxin B1 (AFB1) with vitamin K, phenylbutazone, and sulfamethoxine were investigated in albino rats. Vitamin K (5 mg/kg) was able to completely suppress the increase in whole blood clotting time caused by AFB1 (25 micrograms/kg). Phenylbutazone (50
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