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生物来源
plant (Silybum marianum)
质量水平
表单
powder
技术
toxicology assay: suitable
应用
microbiology
储存温度
−20°C
SMILES字符串
O1C(C(Oc3c1ccc(c3)C4Oc5c(c(cc(c5)O)O)C(=O)C4O)c2cc(c(cc2)O)OC)CO
InChI
1S/C25H22O10/c1-32-17-6-11(2-4-14(17)28)24-20(10-26)33-16-5-3-12(7-18(16)34-24)25-23(31)22(30)21-15(29)8-13(27)9-19(21)35-25/h2-9,20,23-29,31H,10H2,1H3
InChI key
SEBFKMXJBCUCAI-UHFFFAOYSA-N
一般描述
水飞蓟素是一种黄酮木脂素，来自奶蓟（水飞蓟）植物。
应用
水飞蓟素已用于研究：
- 其体外抗病毒、抗菌、抗真菌活性及细胞毒性
- 水飞蓟素对环磷酰胺 (CYP) 诱导的膀胱炎大鼠模型膀胱收缩的影响
- 其对伏马菌素 B1 诱导的小鼠肝脏中毒的影响
生化/生理作用
水飞蓟素对大鼠缺血再灌注诱导的心肌梗死具有心脏保护活性。
水飞蓟素最初是众所周知的保护肝脏免受各种有毒物质侵害的药物，并用于治疗肝炎和肝硬化。水飞蓟素具有抗纤维化、抗脂质过氧化、抗炎、免疫调节和膜稳定等多种生物学作用。水飞蓟素还有助于肝再生。
水飞蓟素通过降低血清丙氨酸氨基转移酶 (ALT)、天门冬氨酸氨基转移酶 (AST) 和碱性磷酸酶 (ALP) 水平来保护肝脏免受抗结核药物的细胞毒作用。这种作用与水飞蓟素的抗氧化作用有关。
其他说明
水飞蓟 果实中抗肝毒性黄酮醇木脂素的混合物。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Effect of silymarin on bladder overactivity in cyclophosphamide-induced cystitis rat model
Eser N, et al.
Phytomedicine, 19(8-9), 840-845 (2012)
Sirajudheen Anwar et al.
Indian journal of pharmacology, 50(3), 108-115 (2018-09-01)
Silymarin, extracted from the seeds of Silybum marianum L. (Milk thistle), is traditionally used for treating various illnesses such as diabetes, cancer, inflammation, hepatitis, liver cirrhosis, and renal problems. Acute cytotoxicity and genotoxicity studies have been reported with ambiguous outcomes;
Vieri Piazzini et al.
Molecules (Basel, Switzerland), 24(9) (2019-05-06)
Two novel nanomicellar formulations were developed to improve the poor aqueous solubility and the oral absorption of silymarin. Polymeric nanomicelles made of Soluplus and mixed nanomicelles combining Soluplus with d-α-tocopherol polyethylene glycol 1000 succinate (vitamin E TPGS) were prepared using
Silymarin protects liver against toxic effects of anti-tuberculosis drugs in experimental animals.
Eminzade, S.
Nutrition & Metabolism, 5, 18-18 (2008)
Laise Mara Oliveira Miranda et al.
Biomedical and environmental sciences : BES, 33(9), 690-700 (2020-10-28)
To evaluate the efficiency of silymarin (SMN) in modulating metabolic parameters and redox status in rats with type 1 diabetes mellitus (T1DM). Diabetes was induced by intraperitoneal injection of alloxan. The diabetic rats were administered with SMN at doses of
商品
抗氧化剂可保护生物系统免受含氧自由基和氧化还原过渡金属离子（如铁、铜和镉）引起的氧化损伤。
Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.
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