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生物来源
plant (Silybum marianum)
质量水平
表单
powder
技术
toxicology assay: suitable
应用
microbiology
储存温度
−20°C
SMILES字符串
O1C(C(Oc3c1ccc(c3)C4Oc5c(c(cc(c5)O)O)C(=O)C4O)c2cc(c(cc2)O)OC)CO
InChI
1S/C25H22O10/c1-32-17-6-11(2-4-14(17)28)24-20(10-26)33-16-5-3-12(7-18(16)34-24)25-23(31)22(30)21-15(29)8-13(27)9-19(21)35-25/h2-9,20,23-29,31H,10H2,1H3
InChI key
SEBFKMXJBCUCAI-UHFFFAOYSA-N
一般描述
水飞蓟素是一种黄酮木脂素，来自奶蓟（水飞蓟）植物。
应用
水飞蓟素已用于研究：
- 其体外抗病毒、抗菌、抗真菌活性及细胞毒性
- 水飞蓟素对环磷酰胺 (CYP) 诱导的膀胱炎大鼠模型膀胱收缩的影响
- 其对伏马菌素 B1 诱导的小鼠肝脏中毒的影响
生化/生理作用
水飞蓟素对大鼠缺血再灌注诱导的心肌梗死具有心脏保护活性。
水飞蓟素最初是众所周知的保护肝脏免受各种有毒物质侵害的药物，并用于治疗肝炎和肝硬化。水飞蓟素具有抗纤维化、抗脂质过氧化、抗炎、免疫调节和膜稳定等多种生物学作用。水飞蓟素还有助于肝再生。
水飞蓟素通过降低血清丙氨酸氨基转移酶 (ALT)、天门冬氨酸氨基转移酶 (AST) 和碱性磷酸酶 (ALP) 水平来保护肝脏免受抗结核药物的细胞毒作用。这种作用与水飞蓟素的抗氧化作用有关。
其他说明
水飞蓟 果实中抗肝毒性黄酮醇木脂素的混合物。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Nuriye Ezgi Bektur Aykanat et al.
Pharmacological reports : PR, 72(1), 199-207 (2020-02-06)
14 million people are diagnosed with new cancer and approximately 8 million people die from cancer every year. Hepatocellular carcinoma is the most common type of liver cancer and covers almost 5-6% of cancer deaths worldwide. Silybum marianum, a plant
Protective effects of silymarin on fumonisin B1-induced hepatotoxicity in mice
Sozmen M, et al.
Journal of Veterinary Science, 15(1), 51-60 (2012)
Multitargeted therapy of cancer by silymarin
Ramasamy K and Agarwal R
Cancer letters, 269(2), 352-362 (2008)
Chun-Ping Lu et al.
Chemico-biological interactions, 290, 12-18 (2018-05-14)
Macrophages and inflammasome pathway are involved in high-glucose toxicity and development of insulin resistance. Silymarin (SMR) was known to modulate glucose homeostasis and reduce inflammation. However, it is still unknown whether SMR possess anti-hyperglycemic effects in diabetic-like knockout mice (Hnf-1αkin/-/Ins.cre
Verônica de Souza Santos et al.
Life sciences, 228, 305-315 (2019-05-03)
Silymarin, an extract from Silybum marianum (milk thistle) containing a standardized mixture of flavonolignans that ameliorates some types of liver disease and, more recently, kidney damage, could be used for the ROS-scavenging effect of these antioxidants. Furthermore, contrast-induced nephropathy (CIN)
商品
Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.
抗氧化剂可保护生物系统免受含氧自由基和氧化还原过渡金属离子（如铁、铜和镉）引起的氧化损伤。
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