生物来源
mouse
质量水平
重组
expressed in E. coli
检测方案
≥97% (SDS-PAGE)
形式
lyophilized powder
效能
0.4-3.0 μg/mL ED50
分子量
predicted mol wt 20 kDa
包装
pkg of 25 μg
储存条件
avoid repeated freeze/thaw cycles
杂质
<1 EU/μg
UniProt登记号
储存温度
−20°C
基因信息
mouse ... Shh(20423)
一般描述
Sonic hedgehog (Shh) is a morphogenic glycoprotein. The gene encoding it is localized on mouse chromosome 5.
应用
Sonic hedgehog peptide from mouse has been used for neural differentiation.
生化/生理作用
Cell signaling peptide involved in embryonic morphogenic development of several tissues including Hensen′s node, the notochord, and the neural tube.
Sonic hedgehog (Shh) has a role in fracture healing and regeneration. The protein associates with its receptor Patched (Ptc-1), de-represses Smoothened (Smo) and activates the Gli family of transcription factors. Mutations in the Shh pathway have been linked to developmental diseases and cancer.
其他说明
N-terminal peptide encoding amino acid residues 25-198.
外形
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline, pH 7.4, containing 5% trehalose and 50 μg of bovine serum albumin per 1 μg of cytokine.
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
含少量动物源组分生物产品
常规特殊物品
Na Song et al.
Experimental and therapeutic medicine, 15(6), 5084-5090 (2018-05-29)
Diabetes mellitus (DM) complications affect patients and cause varying damage. Skin ulcers exhibit difficulties in wound healing, and the regulatory basis for this remains unclear. High glucose concentration (HG) was utilized to mimic DM in cultured cells. Reverse transcription-quantitative polymerase
Abolghasem Esmaeili et al.
Avicenna journal of medical biotechnology, 6(1), 21-26 (2014-02-20)
Stem cells from Human Exfoliated Deciduous teeth (SHED) have the capability to differentiate into neural cells. Neurotrophins including Nerve Growth Factor (NGF), Brain-Derived Neurotrophic Factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4) have neurogenesis, neurotrophic, or neuroprotective effects and are expressed
Sanming Li et al.
Journal of cellular and molecular medicine, 22(1), 230-240 (2017-08-08)
Ectodysplasin A (Eda), a member of the tumour necrosis factor superfamily, plays an important role in ectodermal organ development. An EDA mutation underlies the most common of ectodermal dysplasias, that is X-linked hypohidrotic ectodermal dysplasia (XLHED) in humans. Even though
Sonic hedgehog stimulates neurite outgrowth in a mechanical stretch model of reactive-astrogliosis.
Berretta A
Scientific Reports, 6, 21896-21896 (2016)
Expression and Role of Sonic Hedgehog in the Process of Fracture Healing with Aging.
Matsumoto K
In Vivo, 30(2), 99-105 (2016)
商品
培养和表征CSC群体的癌症干细胞培养基、球状体培养板和癌症干细胞标志物。
Cancer stem cell media, spheroid plates and cancer stem cell markers to culture and characterize CSC populations.
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