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Merck
CN

RES6007H-A7

SAFC

HEPES钠盐 钠盐

制药生产

别名:

4-(2-羟乙基)哌嗪-1-乙磺酸 钠盐, N-(2-羟乙基)哌嗪-N′-(2-乙磺酸) 钠盐

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About This Item

经验公式(希尔记法):
C8H17N2NaO4S
CAS号:
分子量:
260.29
EC 号:
MDL编号:
UNSPSC代码:
12161700
NACRES:
NA.21

生物来源

synthetic

质量水平

表单

powder

技术

cell culture | mammalian: suitable

杂质

Endotoxin, microbial, and trace metals; tested

有效pH范围

6.8-8.2

pKa (25 °C)

7.5

适用性

suitable for manufacturing use

异质活性

Cytotoxicity, DNase, NICKase, RNase, and Protease; tested

SMILES字符串

[Na+].OCCN1CCN(CC1)CCS([O-])(=O)=O

InChI

1S/C8H18N2O4S.Na/c11-7-5-9-1-3-10(4-2-9)6-8-15(12,13)14;/h11H,1-8H2,(H,12,13,14);/q;+1/p-1

InChI key

RDZTWEVXRGYCFV-UHFFFAOYSA-M

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一般描述

我们用于生物制药加工的SAFC®系列优质原料经过严格的质量控制流程,配合记录文件和技术专长帮助我们的客户达到M-Clarity 计划规定的要求

M-Clarity 计划

缓冲液质量是生物制药工艺成功的关键,因为缓冲液几乎在每一个生产步骤中都是必不可少的。

我们广泛的缓冲材料产品线经过妥善管控,可根据您的需求量身定制。从低风险应用的非 GMP 等级,到高风险应用的 IPEC-PQG GMP标准,我们的产品可满足您的所有制造需求。

应用

HEPES是一种生物缓冲液,通常被称为Good′s缓冲液。HEPES钠盐与HEPES结合使用,是最常用的生物缓冲液配方,该缓冲液的pKa为7.31,与7.36的生理pH对应。HEPES钠盐被认为是对培养细胞系无毒的一种物质高度可溶于水并可为溶液提供高澄清度。

MES那样用于细胞培养基、生物制药缓冲制剂上游和下游以及诊断试剂。

包装

该产品有以下包装尺寸:
RES6007H-A701X: 100g容器
RES6007H-A702X: 1kg容器
RES6007H-A704X: 10kg容器
RES6007H-A705X: 25kg容器

法律信息

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

替代产品

产品编号
说明
价格

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

Qing Dai et al.
Analytical chemistry, 83(17), 6559-6564 (2011-08-02)
A ratiometric fluorescence sensor based on pyrene was designed for selective detection of heparin in HEPES (N-(2-hydroxyethyl)piperazine-N'-ethanesulfonic acid) buffer and serum sample. Pyrene and long-chain alkanes were linked through bisquaternary functionality in the sensor which could interact with heparin via
Rakesh Kumar Pathak et al.
The Analyst, 137(17), 4069-4075 (2012-07-24)
A highly fluorescent Zn(2+) complex of the triazole linked salicyl-imino-thiophenyl conjugate of calix[4]arene, [ZnL] has been demonstrated to be a chemo-sensing ensemble for the recognition of His and Cys among the naturally occurring amino acids in HEPES buffer milieu. The
J R Eidet et al.
Experimental eye research, 94(1), 109-116 (2011-12-14)
The use of amniotic membrane (AM) represents one of the major developments in ocular surface reconstruction. However, in a study on patients with primary pterygium, transplantation of AM with ex vivo expanded human conjunctival epithelial cells (HCjE) promoted earlier epithelialization
Tina Vognsen et al.
Biochemical and biophysical research communications, 420(1), 188-192 (2012-03-15)
The crystal structure of the NTF2-like domain of the Drosophila homolog of Ras GTPase SH3 Binding Protein (G3BP), Rasputin, was determined at 2.7Å resolution. The overall structure is highly similar to nuclear transport factor 2: It is a homodimer comprised
S Hugel et al.
British journal of pharmacology, 166(8), 2402-2416 (2012-03-29)
Artificial buffers such as HEPES are extensively used to control extracellular pH (pH(e) ) to investigate the effect of H(+) ions on GABA(A) receptor function. In neurones cultured from spinal cord dorsal horn (DH), dorsal root ganglia (DRG) and cerebellar

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