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Merck
CN

RES0114M-A7

SAFC

MES 钠盐

制药生产

别名:

2-(N-吗啉基)乙磺酸 钠盐, 4-吗啉乙磺酸 钠盐

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About This Item

经验公式(希尔记法):
C6H12NNaO4S
CAS号:
分子量:
217.22
Beilstein:
3765682
EC 号:
MDL编号:
UNSPSC代码:
12161700
NACRES:
NA.21

生物来源

synthetic

质量水平

表单

powder

技术

cell culture | mammalian: suitable

杂质

Endotoxin and microbial, tested

有效pH范围

5.5-6.7

pKa 

6.1

适用性

suitable for manufacturing use

异质活性

Cytotoxicity, DNase, NICKase, RNase, and Protease; tested

SMILES字符串

[Na+].[O-]S(=O)(=O)CCN1CCOCC1

InChI

1S/C6H13NO4S.Na/c8-12(9,10)6-3-7-1-4-11-5-2-7;/h1-6H2,(H,8,9,10);/q;+1/p-1

InChI key

IRHWMYKYLWNHTL-UHFFFAOYSA-M

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一般描述

我们用于生物制药加工的SAFC®系列优质原料经过严格的质量控制流程,配合记录文件和技术专长帮助我们的客户达到M-Clarity 计划规定的要求

M-Clarity 计划

缓冲液质量是生物制药工艺成功的关键,因为缓冲液几乎在每一个生产步骤中都是必不可少的。

我们广泛的缓冲材料产品线经过妥善管控,可根据您的需求量身定制。从低风险应用的非 GMP 等级,到高风险应用的 IPEC-PQG GMP标准,我们的产品可满足您的所有制造需求。

应用

HEPES是一种生物缓冲液,通常被称为Good′s缓冲液。MES的pKa为5.96,这使MES成为细胞培养基和基于蛋白质的缓冲液配方的理想候选者,以维持溶液中的稳定环境。MES钠盐被认为是对培养细胞系无毒的一种物质高度可溶于水并可为溶液提供高澄清度。

MES那样用于细胞培养基、生物制药缓冲制剂上游和下游以及诊断试剂。基于MES的缓冲液可用于抗体、肽、蛋白质和血液成分的纯化生物过程。

包装

该产品有以下包装尺寸:
RES0114M-A701X: 100g容器
RES0114M-A702X:1kg包装
RES0114M-A704X: 10kg容器
RES0114M-A705X: 25kg容器

法律信息

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

替代产品

产品编号
说明
价格

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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Tsuyoshi Shirai et al.
Journal of molecular biology, 321(5), 879-889 (2002-09-11)
The crystal structure of congerin II, a galectin family lectin from conger eel, was determined at 1.45A resolution. The previously determined structure of its isoform, congerin I, had revealed a fold evolution via strand swap; however, the structure of congerin
Yue Yuan et al.
Biochemistry, 50(34), 7350-7360 (2011-08-03)
This study is aimed at investigating the molecular basis of environmental adaptation of woolly mammoth hemoglobin (Hb) to the harsh thermal conditions of the Pleistocene ice ages. To this end, we have carried out a comparative biochemical-biophysical characterization of the
Takamitsu Miyafusa et al.
Acta crystallographica. Section F, Structural biology and crystallization communications, 64(Pt 6), 512-515 (2008-06-10)
Capsular polysaccharides (CPs) are important virulence factors of Staphylococcus aureus. The biosynthesis of type 5 and type 8 CPs (CP5 and CP8), which are produced by most clinical isolates of S. aureus, is catalyzed by 16 CP-assembling proteins. One of
Theresa E Bankston et al.
Journal of chromatography. A, 1217(14), 2123-2131 (2010-03-03)
Hydroxyapatite (HAP) columns, widely used for chromatographic separation of proteins and other biomolecules because of their unique selectivity and ability to resolve complex mixtures, exhibit limited stability at acidic conditions requiring careful control of pH. Even with buffered solutions, however
Ekta G Ahuja et al.
Acta crystallographica. Section D, Biological crystallography, 60(Pt 6), 1129-1131 (2004-05-26)
Phenazines are broad-spectrum antibiotic metabolites produced by organisms such as Pseudomonas and Streptomyces. Phenazines have been shown to enhance microbial competitiveness and the pathogenic potential of the organisms that synthesize them. PhzA (163 residues, approximate molecular weight 18.7 kDa) is

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