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种属反应性
human
技术
ELISA: suitable
输入
sample type plasma
sample type cell culture supernatant(s)
sample type serum
assay range
inter-assay cv: <12%
intra-assay cv: <10%
运输
wet ice
储存温度
−20°C
基因信息
human ... IL12RB2(3595)
一般描述
The IL12RB2 (interleukin 12 receptor subunit β 2) gene is mapped to human chromosome 1p31.3 and codes for the β2 chain (130 kDa) of IL-12 receptor.
This ELISA antibody pair detects human IL-12 R beta 2. Other species not yet determined.
应用
For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.
Please refer to the attached Protocolfor details.
生化/生理作用
Il12rb2 (interleukin 12 receptor subunit β 2) stimulates the release of interferon γ and Th1 (T helper cell 1) cell differentiation, as a part of autoimmune response. Il12rb2′s major function is associated with cell mediated immune system. In mice model, deletion of L12RB2 gene is associated with autoimmune and malignant disorders.
其他说明
A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.
警示用语：
Warning
危险声明
预防措施声明
危险分类
Met. Corr. 1
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
IL12RB2 Polymorphisms correlate with risk of lung adenocarcinoma.
Prigione I, et al.
Immunobiol., 221(2), 291-299 (2016)
Identification of susceptibility SNPs in IL10 and IL23R-IL12RB2 for Behcet's disease in Han Chinese.
Yu H, et al.
The Journal of Allergy and Clinical Immunology, 139(2), 621-627 (2017)
Association study of rs924080 and rs11209032 polymorphisms of IL23R-IL12RB2 in a Northern Chinese Han population with Behcet?s disease.
Qin X, et al.
Human immunology, 77(12), 1284-1290 (2016)
An ankylosing spondylitis-associated genetic variant in the IL23R-IL12RB2 intergenic region modulates enhancer activity and is associated with increased Th1-cell differentiation.
Roberts A R, et al.
Annals of the Rheumatic Diseases (2016)
Nahoko Kato-Kogoe et al.
Immunogenetics, 68(1), 55-65 (2015-11-11)
Interleukin 12 receptor β chain (IL12RB2) is a crucial regulatory factor involved in cell-mediated immune responses, and genetic variants of the gene encoding IL12RB2 are associated with susceptibility to various immune-related diseases. We previously demonstrated that haplotypes with single nucleotide
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