产品名称
人组织蛋白酶D ELISA, for serum, plasma and cell culture supernatants
species reactivity
human
packaging
kit of 96 wells (12 strips x 8 wells)
technique(s)
ELISA: suitable
input
sample type cell culture supernatant(s)
sample type plasma
sample type serum
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 50 pg/mL
standard curve range: 0.049-12 ng/mL
detection method
colorimetric
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... CTSD(1509)
Application
For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.
Please refer to the attached Protocolfor details.
Biochem/physiol Actions
Cathepsin D encoded by CTSD gene, is an aspartyl protease, plays a major role in degradation of intracellular and endocytosed protein, for maintenance of tissue homeostasis and metabolism. Cathepsin D works as an endopeptidase in the acidic environment of lysosomes. Cathepsin D is part of signal transduction and a potential target for various cancer. Increased levels of Cathepsin D is associated with type 2 diabetes. Cathepsin D regulates sphingolipid metabolism and cholesterol trafficking. Genetic variations in Cathepsin D gene is a risk factor for Alzheimer′s disease and neuronal ceroid lipofuscinosis. Cathepsin D is a key marker in atherosclerosis and level of expression is increased in atherosclerotic lesions. Cathepsin D regulates the degradation of advanced glycation end products (AGEs) and impaired activity of cathepsin D results in accumulation of AGEs in photoaged skin. Increased plasma concentration of Cathepsin D causes non-alcoholic steatohepatitis (NASH) leading to hepatic lipid accumulation and inflammation.
General description
This ELISA antibody pair detects human Cathepsin D. Other species not yet determined.
Other Notes
A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Met. Corr. 1
存储类别
8A - Combustible corrosive hazardous materials
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Correlation between cathepsin D serum concentration and carotid intima-media thickness in hemodialysis patients
Moallem SA, et al.
International Urology and Nephrology, 43(3), 841-848 (2011)
Cathepsin D, a lysosomal protease, regulates ABCA1-mediated lipid efflux
Haidar B, et al.
The Journal of Biological Chemistry, 281(52), 39971-39981 (2006)
Increased Cathepsin D Correlates with Clinical Parameters in Newly Diagnosed Type 2 Diabetes
Liu L, et al.
Disease Markers, 2017 (2017)
Plasma cathepsin D correlates with histological classifications of fatty liver disease in adults and responds to intervention
Walenbergh SMA, et al.
Scientific Reports, 6(3), 38278-38278 (2016)
Cathepsin D contributes to the accumulation of advanced glycation end products during photoaging
Xu X, et al.
Journal of Dermatological Science, 90(3), 263-275 (2018)
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