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种属反应性
mouse
包装
kit of 96 wells (12 strips x 8 wells)
技术
ELISA: suitable
输入
sample type serum sample(s)
sample type cell culture supernatant(s)
sample type plasma
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 0.8 ng/ml
检测方法
colorimetric
运输
wet ice
储存温度
−20°C
基因信息
mouse ... Grem1(23892)
一般描述
Gremlin-1 (GREM1) is part of the secreted, cysteine knot DAN family of bone morphogenetic protein antagonists. It has a molecular weight of 24–26kDa.
应用
For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.
Please refer to the attached Protocolfor details.
生化/生理作用
Gremlin-1 (GREM1) has a role in embryogenesis. It also has a role in cell functions during development. GREM1 acts as an antagonist of bone morphogenetic proteins (BMP). The protein influences chondrogenesis, outgrowth and apoptosis in limb bud development and has a role in kidney formation. It inhibits the activity of BMP2 and BMP4. GREM1 is involved in angiogenesis, bone formation, bone mass and pulmonary hypertension. Knockout of this gene in mice leads to developmental abnormalities.
其他说明
A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.
警示用语：
Warning
危险声明
预防措施声明
危险分类
Met. Corr. 1
储存分类代码
8A - Combustible corrosive hazardous materials
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Allelic Depletion of grem1 Attenuates Diabetic Kidney Disease
Roxburgh SA, et al.
Diabetes, 58(7), 1641-1650 (2009)
Treatment with anti-gremlin 1 antibody ameliorates chronic hypoxia/SU5416-induced pulmonary arterial hypertension in mice.
Ciuclan L, et al.
The American Journal of Pathology, 183(5), 1461-1473 (2013)
Gremlin1 plays a key role in kidney development and renal fibrosis.
Church RH, et al.
American Journal of Physiology: Renal Physiology, 312(6), F1141-F1157 (2017)
Vital Roles of Gremlin-1 in Pulmonary Arterial Hypertension Induced by Systemic-to-Pulmonary Shunts.
Liukun Meng et al.
Journal of the American Heart Association, 9(15), e016586-e016586 (2020-08-05)
Background Heterozygous mutation in BMP (bone morphogenetic protein) receptor 2 is rare, but BMP cascade suppression is common in congenital heart disease-associated pulmonary arterial hypertension (CHD-PAH); however, the underling mechanism of BMP cascade suppression independent of BMP receptor 2 mutation
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