species reactivity
human
packaging
kit of 96 wells (12 strips x 8 wells)
technique(s)
ELISA: suitable
input
sample type plasma
sample type serum sample(s)
sample type cell culture supernatant(s)
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 8 pg/mL
detection method
colorimetric
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... GHRL(51738)
General description
This ELISA antibody pair detects Human Ghrelin (GHRL)
Application
For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.
Please refer to the attached Protocolfor details.
Biochem/physiol Actions
The peptide ghrelin, one of the cleavage products of prepropeptide produced from the GHRL (growth hormone-releasing peptide) gene, functions in stimulating food intake and controlling energy balance. It has potent stimulating effects on the secretion of growth hormone. GHRL serves as an endogenous ligand for the growth hormone secretagogue receptor 1α (GHSR 1α). The protein regulates body weight on long-term and appetite on short-term. Preadipocyte differentiation stimulated by ghrelin is found to increase BMI and negatively regulate the anorexigenic effect of leptin. Polymorphism in the GHRL gene is linked to variations in blood pressure, high-density lipoproteins, low-density lipoproteins, serum cholesterol, blood glucose and metabolic syndrome.
Other Notes
A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Met. Corr. 1
存储类别
8A - Combustible corrosive hazardous materials
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Atsushi Kuroda et al.
Geriatrics & gerontology international, 18(6), 886-891 (2018-02-15)
Alzheimer's disease causes loss of appetite, resulting in bodyweight reduction. This, in turn, causes progression of cognitive dysfunction and physical complications that hasten death. Earlier care for loss of appetite is essential in Alzheimer's disease management. Rivastigmine is a therapeutic
T F Lobo et al.
Journal of endocrinological investigation, 42(2), 149-156 (2018-04-27)
The study of adipokines in overweight women with early-onset (diagnosed before 20 weeks) gestational diabetes mellitus (GDM) could help to understand the ethiopathological mechanisms of this disorder. Our aim was to assess adipokine levels in overweight pregnant women with early-onset GDM
Kalina Duszka et al.
PloS one, 15(4), e0232099-e0232099 (2020-04-25)
Food cues affect hunger and nutritional choices. Omnipresent stimulation with palatable food contributes to the epidemics of obesity. The objective of the study was to investigate the impact of food cues on appetite-related hormones and to assess the functionality of
Pouneh K Fazeli et al.
The Journal of clinical psychiatry, 79(1) (2018-01-13)
To assess the effects of relamorelin-an agonist of the appetite-stimulating hormone ghrelin, which has effects on gastric emptying-on (1) weight gain and (2) gastric emptying in women with anorexia nervosa. In a randomized, double-blind, placebo-controlled design, the effects of the
A Lindqvist et al.
Molecular and cellular endocrinology, 511, 110835-110835 (2020-05-07)
It is not known how ghrelin affects insulin secretion in human islets from patients with type 2 diabetes (T2D) or whether islet ghrelin expression or circulating ghrelin levels are altered in T2D. Here we sought out to identify the effect
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