产品名称
人半乳凝素-8 ELISA试剂盒, for cell culture supernatants, plasma, and serum samples
species reactivity
human
packaging
kit of 96 wells (12 strips x 8 wells)
technique(s)
ELISA: suitable
input
sample type plasma
sample type serum sample(s)
sample type cell culture supernatant(s)
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 0.16 ng/ml
detection method
colorimetric
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... LGALS8(3964)
Application
For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.
Please refer to the attached Protocolfor details.
Biochem/physiol Actions
Galectin-8 (Gal-8) is a member of “tandem-repeat” galectin family, possesses two carbohydrate binding domains linked by a short peptide. The short peptide accounts for Gal-8 cell adhesion and downstream signalling. Tumor cells, as well as normal tissues, express Gal-8. The expression level of Gal-8 is higher in multiple myeloma conditions and enhances adhesion to vascular endothelium. Galectin-8 binds to integrin selectively and inhibits cell adhesion and promotes apoptosis. Gal-8 interacts with integrin alpha and regulates neutrophil adhesion to endothelial cells and migration. Gal-8 ligand binds to cluster of differentiation 44 (CD44) and causes an inflammatory response in rheumatoid arthritis. Overexpression of Gal-8 plays a key role in metastasis of prostate cancer and cell survival by causing rearrangement of the cytoskeleton and E-cadherin expression.
General description
This ELISA antibody pair detects Human Galectin-8 (LGALS8)
Other Notes
A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Met. Corr. 1
存储类别
8A - Combustible corrosive hazardous materials
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Galectin-8 modulates neutrophil function via interaction with integrin alphaM
Nishi N, et al.
Glycobiology, 13(11), 755-763 (2003)
Stable and high expression of Galectin-8 tightly controls metastatic progression of prostate cancer
Gentilini LD, et al.
Oncotarget, 8(27), 44654-44668 (2017)
The involvement of CD44 and its novel ligand galectin-8 in apoptotic regulation of autoimmune inflammation
Sebban LE, et al.
Journal of Immunology, 179(2), 1225-1235 (2007)
Galectin-8 enhances adhesion of multiple myeloma cells to vascular endothelium and is an adverse prognostic factor
Friedel M, et al.
Glycobiology, 26(10), 1048-1058 (2016)
Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis
Hadari YR, et al.
Journal of Cell Science, 113(13), 2385-2397 (2000)
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