种属反应性
human
包装
kit of 96 wells (12 strips x 8 wells)
技术
ELISA: suitable
输入
sample type serum sample(s)
sample type cell culture supernatant(s)
sample type plasma
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 0.3 ng/ml
检测方法
colorimetric
运输
wet ice
储存温度
−20°C
基因信息
human ... FGF23(8074)
一般描述
The FGF23 (fibroblast growth factor 23) gene is mapped to human chromosome 12p13.32 and encodes a phosphaturic hormone secreted by osteocytes. FGF23 is a 30 kDa protein and is part of the FGF19 subfamily.
This ELISA antibody pair detects Human FGF-23
应用
For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.
Please refer to the attached Protocolfor details.
生化/生理作用
The protein fibroblast growth factor 23 (FGF23) mainly controls phosphate homeostasis and induces its excretion. Fgf23 maintains normal serum phosphate and calcium levels, by suppressing the action of sodium phosphate co-transporters and 25-hydroxyvitamin D 1-α-hydroxylase. Deficiency of the encoded protein causes chronic kidney disease. Leptin, a protein highly expressed in obesity is known influence the expression of this protein. Thus, higher FGF23 gene expression is observed in obese individuals. The FGF23 gene affects cardiac properties and is associated with cardiovascular risk factors such as alcoholism.
其他说明
A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.
警示用语：
Warning
危险声明
预防措施声明
危险分类
Met. Corr. 1
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
The discovery of ?-Klotho and FGF23 unveiled new insight into calcium and phosphate homeostasis.
Nabeshima Y
Cellular and Molecular Life Sciences, 65(20), 3218-3218 (2008)
Fibroblast growth factor 23: state of the field and future directions.
Bhattacharyya N, et al.
Trends in Endocrinology and Metabolism, 23(12), 610-618 (2012)
Dietary factors and fibroblast growth factor-23 levels in young adults with African ancestry.
Kosk D, et al.
Journal of Bone and Mineral Metabolism, 35(6), 666-674 (2017)
Decreased Expression of Thrombomodulin in Endothelial Cells by Fibroblast Growth Factor?23/??Klotho.
Tanaka K, et al.
Therapeutic Apheresis and Dialysis : Official Peer-Reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy, 21(4), 395-404 (2017)
Cardiac Changes and Their Association with Fetuin-A and Fibroblast Growth Factor-23 in Children with Chronic Kidney Disease.
Mudi A, et al.
Nephron, 136(3), 233-242 (2017)
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