species reactivity
human
technique(s)
ELISA: suitable
assay range
inter-assay cv: <10%
intra-assay cv: <12%
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... BTK(695)
Application
请参考Protocol了解详情。
General description
Bruton tyrosine kinase (BTK) belongs to the Tec family of kinases. It is expressed in multiple hematopoietic cells. It plays a role in B-cell activation, maturation, development, and B-cell receptor (BCR)-signaling. Mutations in the BTK gene are associated with an inherited disorder, X-linked agammaglobulinemia. The BTK gene is located on the human chromosome at Xq22.1.
The antibody pair provided in this kit recognizes Human Tyrosine-Phosphorylated-BTK.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Met. Corr. 1
存储类别
8A - Combustible corrosive hazardous materials
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Bruton's Tyrosine Kinase (BTK) Is a Novel KMT2A Partner Gene
Zerkalenkova E
Blood (2019)
Bruton's Tyrosine Kinase (BTK) Is a Novel KMT2A Partner Gene
Zerkalenkova E
Blood (2019)
Sarah E M Herman et al.
Blood, 117(23), 6287-6296 (2011-03-23)
B-cell receptor (BCR) signaling is aberrantly activated in chronic lymphocytic leukemia (CLL). Bruton tyrosine kinase (BTK) is essential to BCR signaling and in knockout mouse models its mutation has a relatively B cell-specific phenotype. Herein, we demonstrate that BTK protein
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