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种属反应性
human
包装
kit of 96 wells (12 strips x 8 wells)
技术
ELISA: suitable
输入
sample type serum
sample type plasma
sample type cell culture supernatant(s)
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 40 pg/mL
standard curve range: 40.96-10000 pg/mL
检测方法
colorimetric
运输
wet ice
储存温度
−20°C
基因信息
human ... UMOD(7369)
一般描述
The UMOD ELISA kit provides for the Quantitative measurement of Uromodulin in Cell Culture Supernatants, Plasma and Serum.
Uromodulin also known as Tamm-Horsfall protein (THP) is a glycoprotein localized in the thick ascending limb (TAL) of the Henle loop in the kidney. It is the most abundant protein excreted in the urine. Uromodulin plays a role in preventing urinary tract infections and kidney stones. It aids in immunomodulation and regulation of ion transport in TAL. Uromodulin acts as an inverse biomarker in the early detection of chronic kidney disorders.
应用
For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Human UMOD / Uromodulin ELISA Kit has been used to measure the levels of Tamm-Horsfall protein (THP) in human plasma samples.
其他说明
A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.
Please type the word sample in the text box provided for lot number.
警示用语：
Warning
危险声明
预防措施声明
危险分类
Met. Corr. 1
储存分类代码
8A - Combustible corrosive hazardous materials
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Olivier Devuyst et al.
Nature reviews. Nephrology, 13(9), 525-544 (2017-08-07)
Uromodulin (also known as Tamm-Horsfall protein) is exclusively produced in the kidney and is the most abundant protein in normal urine. The function of uromodulin remains elusive, but the available data suggest that this protein might regulate salt transport, protect
Kaice A LaFavers et al.
Science translational medicine, 11(512) (2019-10-04)
High serum concentrations of kidney-derived protein uromodulin [Tamm-Horsfall protein (THP)] have recently been shown to be independently associated with low mortality in both older adults and cardiac patients, but the underlying mechanism remains unclear. Here, we show that THP inhibits
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