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安全信息

RAB0751

Sigma-Aldrich

Human UMOD / Uromodulin ELISA Kit

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别名:
THP, Tamm-Horsfall protein, Tamm-Horsfall urinary glycoprotein, Uromodulin
UNSPSC代码:
41116158
NACRES:
NA.84

种属反应性

human

包装

kit of 96 wells (12 strips x 8 wells)

技术

ELISA: suitable

输入

sample type serum
sample type plasma
sample type cell culture supernatant(s)

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 40 pg/mL
standard curve range: 40.96-10000 pg/mL

检测方法

colorimetric

运输

wet ice

储存温度

−20°C

基因信息

human ... UMOD(7369)

相关类别

一般描述

The UMOD ELISA kit provides for the Quantitative measurement of Uromodulin in Cell Culture Supernatants, Plasma and Serum.
Uromodulin also known as Tamm-Horsfall protein (THP) is a glycoprotein localized in the thick ascending limb (TAL) of the Henle loop in the kidney. It is the most abundant protein excreted in the urine. Uromodulin plays a role in preventing urinary tract infections and kidney stones. It aids in immunomodulation and regulation of ion transport in TAL. Uromodulin acts as an inverse biomarker in the early detection of chronic kidney disorders.

应用

For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Human UMOD / Uromodulin ELISA Kit has been used to measure the levels of Tamm-Horsfall protein (THP) in human plasma samples.

其他说明

A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.

试剂盒组分也可单独购买

产品编号
说明
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  • RABWASH420X Wash Buffer (Item B)化学品安全说明书

象形图

Corrosion
GHS05

警示用语：

Warning

危险声明

H290

预防措施声明

P234 - P390

危险分类

Met. Corr. 1

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

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Olivier Devuyst et al.
Nature reviews. Nephrology, 13(9), 525-544 (2017-08-07)
Uromodulin (also known as Tamm-Horsfall protein) is exclusively produced in the kidney and is the most abundant protein in normal urine. The function of uromodulin remains elusive, but the available data suggest that this protein might regulate salt transport, protect
Kaice A LaFavers et al.
Science translational medicine, 11(512) (2019-10-04)
High serum concentrations of kidney-derived protein uromodulin [Tamm-Horsfall protein (THP)] have recently been shown to be independently associated with low mortality in both older adults and cardiac patients, but the underlying mechanism remains unclear. Here, we show that THP inhibits

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