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安全信息

RAB0707

Sigma-Aldrich

人LDLR /低密度脂蛋白受体ELISA试剂盒

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UNSPSC代码:
41116158
NACRES:
NA.32

种属反应性

human

包装

kit of 96 wells (12 strips x 8 wells)

技术

ELISA: suitable

输入

sample type cell culture supernatant(s)
sample type plasma
sample type serum

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 8 pg/mL
standard curve range: 8.19-2000 pg/mL

检测方法

colorimetric

运输

wet ice

储存温度

−20°C

基因信息

human ... LDLR(3949)

一般描述

The antibody pair provided in this kit recognizes human Low-density Lipoprotein Receptor.
LDLR (low density lipoprotein receptor) codes for a transmembrane receptor glycoprotein, containing 860 amino acids and is mapped to human chromosome 19p13.2.

应用

请参考Protocol了解详情。

生化/生理作用

LDLR′s (low density lipoprotein receptor) major function is to regulate the level of lipoprotein particles by mediating the clearance of LDL-cholesterol and triglyceride through receptor mediated endocytosis. LDLR is involved in proliferation by providing cholesterol for membrane synthesis. The LDLR gene is a target for treating cardiovascular diseases. Mutation in the gene causes familial hypercholesterolemia.

其他说明

A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.

试剂盒组分也可单独购买

产品编号
说明
化学品安全说明书

  • RABTMB3ELISA Colorimetric TMB Reagent (HRP Substrate, Item H)化学品安全说明书

  • RABSTOP3ELISA Stop Solution (Item I)化学品安全说明书

  • RABWASH420X Wash Buffer (Item B)化学品安全说明书

象形图

Corrosion

警示用语:

Warning

危险声明

预防措施声明

危险分类

Met. Corr. 1

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

新产品

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ (Lot或Batch)字后找到。

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5-Azacytidine engages an IRE1?-EGFR-ERK1/2 signaling pathway that stabilizes the LDL receptor mRNA.
Mnasri N, et al.
Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, 1861(1), 29-40 (2018)
Daniel S Hsia et al.
The British journal of nutrition, 124(6), 577-585 (2020-04-18)
Cranberries are high in polyphenols, and epidemiological studies have shown that a high-polyphenol diet may reduce risk factors for diabetes and CVD. The present study aimed to determine if short-term cranberry beverage consumption would improve insulin sensitivity and other cardiovascular
Mutational screening in the LDLR gene among patients presenting familial hypercholesterolemia in the Southeast of Brazil.
Molfetta G A, et al.
Genetics and molecular research : GMR, 16(3) (2017)
E Soemirien Kasanmoentalib et al.
Journal of neuroinflammation, 16(1), 279-279 (2019-12-31)
The complement system is a vital component of the inflammatory response occurring during bacterial meningitis. Blocking the complement system was shown to improve the outcome of experimental pneumococcal meningitis. Complement factor H (FH) is a complement regulatory protein inhibiting alternative
Functional analysis of the p.(Leu15Pro) and p.(Gly20Arg) sequence changes in the signal sequence of LDL receptor.
Pavlouskova J, et al.
Atherosclerosis, 250, 9-14 (2016)

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