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种属反应性
mouse
包装
kit of 96 wells (12 strips x 8 wells)
技术
ELISA: suitable
输入
sample type serum
sample type plasma
sample type cell culture supernatant(s)
assay range
inter-assay cv: <10%
intra-assay cv: <12%
sensitivity: 30 pg/mL
检测方法
colorimetric
运输
wet ice
储存温度
−20°C
基因信息
mouse ... Tnfsf4(22164)
一般描述
This ELISA antibody pair detects mouse TNFSF4/OX40.
应用
请参考Protocol了解详情。
生化/生理作用
Tumor necrosis factor (TNF) superfamily member 4 (Tnfsf4) signals specifically through the OX40 receptor, which is expressed primarily on CD4+T cells but also on certain activated CD8+T cells. Tnfsf4 acts as a costimulatory signal, which is essential for a productive interaction between antigen presenting cells and their target T-cells. It enhances cell proliferation and survival and increases expression of regulated on activation, normal T cell expressed and secreted (RANTES) or chemokine ligand 5 (CCL5), interleukins-2 and -3 and interferon γ (IFNg). Tnfsf4 signaling plays an important role in immuno-regulatory communication and immune-tolerance. Polymorphisms in the TNFSF4 gene leads to the development of autoimmune thyroid diseases (AITDs), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and systemic sclerosis (SSc).
其他说明
A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.
Please type the word sample in the text box provided for lot number.
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产品编号
说明
化学品安全说明书
警示用语：
Warning
危险声明
预防措施声明
危险分类
Met. Corr. 1
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Control of immunity by the TNFR-related molecule OX40 (CD134).
Croft M
Annual Review of Immunology, 28, 57-78 (2009)
TNFSF4 Gene Variations Are Related to Early-Onset Autoimmune Thyroid Diseases and Hypothyroidism of Hashimoto?s Thyroiditis
Rong-Hua Song
International Journal of Molecular Sciences, 17(8), 1369-1369 (2016)
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