产品名称
小鼠Tnfsf4 /肿瘤坏死因子配体超家族成员4 ELISA试剂盒, for serum, plasma and cell culture supernatants
species reactivity
mouse
packaging
kit of 96 wells (12 strips x 8 wells)
technique(s)
ELISA: suitable
input
sample type serum
sample type plasma
sample type cell culture supernatant(s)
assay range
inter-assay cv: <10%
intra-assay cv: <12%
sensitivity: 30 pg/mL
detection method
colorimetric
shipped in
wet ice
storage temp.
−20°C
Gene Information
mouse ... Tnfsf4(22164)
Application
请参考Protocol了解详情。
Biochem/physiol Actions
Tumor necrosis factor (TNF) superfamily member 4 (Tnfsf4) signals specifically through the OX40 receptor, which is expressed primarily on CD4+T cells but also on certain activated CD8+T cells. Tnfsf4 acts as a costimulatory signal, which is essential for a productive interaction between antigen presenting cells and their target T-cells. It enhances cell proliferation and survival and increases expression of regulated on activation, normal T cell expressed and secreted (RANTES) or chemokine ligand 5 (CCL5), interleukins-2 and -3 and interferon γ (IFNg). Tnfsf4 signaling plays an important role in immuno-regulatory communication and immune-tolerance. Polymorphisms in the TNFSF4 gene leads to the development of autoimmune thyroid diseases (AITDs), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and systemic sclerosis (SSc).
General description
This ELISA antibody pair detects mouse TNFSF4/OX40.
Other Notes
A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.
Please type the word sample in the text box provided for lot number.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Met. Corr. 1
存储类别
8A - Combustible corrosive hazardous materials
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Control of immunity by the TNFR-related molecule OX40 (CD134).
Croft M
Annual Review of Immunology, 28, 57-78 (2009)
TNFSF4 Gene Variations Are Related to Early-Onset Autoimmune Thyroid Diseases and Hypothyroidism of Hashimoto?s Thyroiditis
Rong-Hua Song
International Journal of Molecular Sciences, 17(8), 1369-1369 (2016)
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