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种属反应性
human
包装
kit of 96 wells (12 strips x 8 wells)
技术
ELISA: suitable
capture ELISA: suitable
输入
sample type cell lysate
sample type tissue lysate
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 10 pg/mL
standard curve range: 8.23-6000 pg/mL
检测方法
colorimetric
运输
wet ice
储存温度
−20°C
基因信息
human ... VEGFA(7422)
一般描述
The Human VEGF ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human VEGF in cell lysate and tissue lysate.
免疫原
Recombinant Human VEGF-A
应用
请参考Protocol了解详情。
生化/生理作用
VEGF (vascular endothelial growth factor) is a potent angiogenic cytokine. It stimulates proliferation and migration of endothelial cells. VEGF induces microvascular permeability by enhancing function of vesicular-vacuolar organelle (VVO). VEGF plays a prominent role in both normal and pathological angiogenesis. Substantial evidence suggests that VEGF is involved in the induction of tumor metastasis and intraocular neovascular syndromes. Increased expression of VEGF causes retinal angiogenesis, thus, inhibition of VEGF using soluble VEGF-receptor chimeric proteins can be considered as a potential therapy for ischemic retinal disease. Polymorphism in VEGF at C (-634) G is linked with diabetic retinopathy in type 2 diabetes. Altered expression of VEGF is also associated with rheumatoid arthritis, Graves′ disease, psoriasis, cardiovascular disease, and peripheral limb disease.
其他说明
A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.
Please type the word sample in the text box provided for lot number.
试剂盒组分也可单独购买
产品编号
说明
化学品安全说明书
- RABDIL6ELISA 5X Sample Diluent Buffer (Item D2)化学品安全说明书
- RABELADEELISA 5X Assay/Sample Diluent Buffer E (Item E2)化学品安全说明书
- RABLYSIS12X Cell Lysis Buffer (Item J)化学品安全说明书
- RABSTOP3ELISA Stop Solution (Item I)化学品安全说明书
- RABTMB3ELISA Colorimetric TMB Reagent (HRP Substrate, Item H)化学品安全说明书
- RABWASH420X Wash Buffer (Item B)化学品安全说明书
警示用语：
Warning
危险声明
预防措施声明
危险分类
Met. Corr. 1
储存分类代码
8A - Combustible corrosive hazardous materials
法规信息
新产品
Miyako Kurihara-Shimomura et al.
International journal of oncology, 56(5), 1093-1100 (2020-04-23)
Mast cells (MCs) are present in the tumor stroma, and MCs that express the mast cell‑specific proteases tryptase and chymase (MCTC) exhibit several tumor‑related functions. It was previously reported that melanoma inhibitory activity (MIA) gene family members, including MIA, MIA2
Piyush Gondaliya et al.
PloS one, 13(11), e0208044-e0208044 (2018-11-30)
The role of DNA methylation has not been enough explored in pathophysiology of diabetic nephropathy (DN). However, according to recent reports it has been inferred that hypermethylation could be one of the principle cause associated with the enhancement of DN.
A common polymorphism in the 5'-untranslated region of the VEGF gene is associated with diabetic retinopathy in type 2 diabetes.
Awata T
Diabetes, 51, 1635-1639 (2002)
Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins.
Aiello LP
Proceedings of the National Academy of Sciences of the USA, 92, 10457-10461 (1995)
Vascular permeability factor/vascular endothelial growth factor: a multifunctional angiogenic cytokine.
Brown LF
EXS, 79, 233-269 (1997)
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