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种属反应性
human
包装
kit of 96 wells (12 strips x 8 wells)
技术
ELISA: suitable
capture ELISA: suitable
输入
sample type plasma
sample type cell culture supernatant(s)
sample type plasma
sample type serum
sample type urine
sample type serum
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 5 pg/mL
standard curve range: 2.74-2000 pg/mL
检测方法
colorimetric
运输
wet ice
储存温度
−20°C
一般描述
The Human sTNF RII ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human sTNF RII in serum, plasma, cell culture supernatants and urine.
免疫原
Recombinant Human TNF RII
应用
请参考Protocol了解详情。
生化/生理作用
Tumor necrosis factor receptor 2 (TNFR2) plays a vital role in inducing signals for various cellular process, including proliferation of thymocytes and peripheral T cells, T cell secretion of granulocyte-macrophage colony-stimulating factor, inhibition of early hematopoiesis, and the inactivation and clearance of TNF by the kidney. Mutation in the gene leads to hematopoietic cell malignancies, neuroblastoma, glioma, cervical and ovarian carcinoma. TRAF2 interacts with TNFR2 and activates NF-kappa B (NF-κB) pathway. TNFR2, which lacks death domains, modulates the effect of other death receptor TNFR1, which induces T cell death. TNFR2 plays an essential role in TNF-α–induced leukocyte-endothelial interaction. TNFR2 is considered as a potential therapeutic alternative, as it has capacity to nullify the common side effects associated with drugs targeting TNF-α or p55.
其他说明
A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.
Please type the word sample in the text box provided for lot number.
试剂盒组分也可单独购买
产品编号
说明
化学品安全说明书
Tumor necrosis factor alpha (TNF-alpha) receptor-II is required for TNF-alpha-induced leukocyte-endothelial interaction in vivo.
Chandrasekharan UM, et al.
Blood, 109(5), 1938-1944 (2007)
The TNF and TNF receptor superfamilies: integrating mammalian biology.
Locksley RM, et al.
Cell, 104(4), 487-501 (2001)
TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40.
Rothe M, et al.
Science, 269(5229), 1424-1427 (1995)
Human tumor necrosis factor receptor p75/80 (CD120b) gene structure and promoter characterization.
Santee SM, et al.
The Journal of Biological Chemistry, 271(35), 21151-21159 (1996)
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