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主要文件

安全信息

RAB0484

Sigma-Aldrich

人骨保护素/ TNFRSF11b ELISA试剂盒

for serum, plasma, cell culture supernatant and urine

别名:

OPG

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选择尺寸

1 EA
¥6,218.64

¥6,218.64

国内现货，预计发货时间2025年4月27日详情

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变更视图
1 EA
¥6,218.64

About This Item

UNSPSC代码:
41116158
NACRES:
NA.32

¥6,218.64

国内现货，预计发货时间2025年4月27日详情

种属反应性

human

包装

kit of 96 wells (12 strips x 8 wells)

技术

ELISA: suitable
capture ELISA: suitable

输入

sample type serum
sample type urine
sample type cell culture supernatant(s)
sample type plasma

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 1 pg/mL
standard curve range: 1.23-900 pg/mL

检测方法

colorimetric

运输

wet ice

储存温度

−20°C

基因信息

human ... TNFRSF11B(4982)

相关类别

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particle size

5 μm

particle size

3 μm

particle size

3 μm

particle size

3 μm

matrix

silica gel, high purity, spherical base material, fully porous particle

matrix

silica gel, high purity, spherical particle platform, fully porous particle

matrix

silica gel, high purity, spherical particle platform, fully porous particle

matrix

silica gel, high purity, spherical particle platform, fully porous particle

separation technique

hydrophilic interaction (HILIC), reversed phase, normal phase

separation technique

reversed phase

separation technique

reversed phase

separation technique

reversed phase

matrix active group

cyano phase

matrix active group

C18 (octadecyl) phase

matrix active group

C18 (octadecyl) phase

matrix active group

C18 (octadecyl) phase

technique(s)

HPLC: suitable, LC/MS: suitable

technique(s)

HPLC: suitable, LC/MS: suitable

technique(s)

HPLC: suitable, LC/MS: suitable

technique(s)

HPLC: suitable, LC/MS: suitable

pore size

180 Å

pore size

120 Å

pore size

120 Å

pore size

120 Å

一般描述

The Human Osteoprotegerin ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human Osteoprotegerin in serum, plasma, cell culture supernatants and urine.

Osteoprotegerin (OPG) is encoded by the gene mapped to human chromosome 8q24.[1] It is a member of the TNFR (tumor necrosis factor receptor) superfamily that can act as a decoy receptor for RANKL (receptor activator of nuclear factor kappa-B ligand) and TRAIL (tumor necrosis factor-related apoptosis-inducing ligand).[2][3] OPG is expressed in a wide variety of tissues, including adult heart, lung, kidney and liver. It is secreted both as a monomeric and a dimeric protein.[4]

免疫原

Recombinant Human OPG

应用

请参考Protocol了解详情。

生化/生理作用

Binding of soluble osteoprotegerin (OPG) to sRANKL (soluble receptor activator of nuclear factor κ-B ligand) inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells. This process leads to excess accumulation of bone and cartilage.[3] Changes in the level of serum OPG are associated with atherosclerosis and cardiovascular disorders(CVDs).[2] It might also be associated with malignancy and plays a regulatory role in multiple myeloma, prostate, breast, bladder and gastric carcinoma.[5] OPG plays a vital role in bone metabolism and is involved in inhibition of ovariectomy-associated bone loss in rats.[4][5] It is also used as a potent biomarker for CVD.[1]

其他说明

A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.

试剂盒组分也可单独购买

产品编号
说明
化学品安全说明书
  • RABELADAELISA 1X Assay/Sample Diluent Buffer A (Item D1)
  • RABELADBELISA 5X Assay/Sample Diluent Buffer B (Item E1)
  • RABSTOP3ELISA Stop Solution (Item I)
  • RABTMB3ELISA Colorimetric TMB Reagent (HRP Substrate, Item H)
  • RABWASH420X Wash Buffer (Item B)

象形图

Corrosion
GHS05

警示用语：

Warning

危险声明

H290

预防措施声明

P234 - P390

危险分类

Met. Corr. 1

储存分类代码

8A - Combustible corrosive hazardous materials

法规信息

新产品

    • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number
    0424K0220
    0424K0178
    0803J0178
    0207J0178
    1026I0178

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    如果您需要特殊版本，可通过批号或批次号查找具体证书。

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    在文件库中查找您最近购买产品的文档。

    访问文档库

    Osteoprotegerin secreted by inflammatory and invasive breast cancer cells induces aneuploidy, cell proliferation and angiogenesis.
    Goswami S and Neelam S-W
    BMC Cancer, 15(1), 935-935 (2015)
    Allison P Garcia et al.
    Journal of clinical pharmacology, 60(2), 209-217 (2019-09-20)
    This pilot study examined how exemestane (an aromatase inhibitor [AI]) affected osteoprotegerin (OPG) urine concentrations in postmenopausal women. Exemestane (25 mg, single dose) was given to 14 disease-free women past menopause in this nonrandomized, open-label study. Before dosing, urine specimens
    Roles and clinical applications of OPG and TRAIL as biomarkers in cardiovascular disease.
    Bernardi S, et al.
    BioMed Research International, 2016, 12-12 (2016)
    Functions of RANKL/RANK/OPG in bone modeling and remodeling.
    Boyce BF and Xing L.
    Archives of Biochemistry and Biophysics, 473(2), 139-146 (2008)
    Polymorphisms in three genes are associated with hemorrhagic stroke.
    Liu W
    Brain and Behavior, 5(11), e00395-e00395 (2015)
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