¥14,517.30
预计发货时间2025年6月03日详情
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种属反应性
human
包装
kit of 96 wells (12 strips x 8 wells)
技术
ELISA: suitable
capture ELISA: suitable
输入
sample type serum
sample type plasma
sample type urine
sample type cell culture supernatant(s)
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 50 pg/mL
standard curve range: 74.07-18000 pg/mL
检测方法
colorimetric
运输
wet ice
储存温度
−20°C
基因信息
human ... SPP1(6696)
1 of 4
此商品 | C33301 | 80038 | D23408 |
|---|---|---|---|
| assay 98% | assay 95% | assay ≥95.0% (GC) | assay 97% |
| Quality Level 100 | Quality Level 200 | Quality Level 200 | Quality Level 100 |
| mp 274-276 °C (lit.) | mp >320 °C (lit.) | mp >300 °C (lit.) | mp 219-221 °C (lit.) |
| form powder | form powder | form - | form powder |
一般描述
The Human OPN ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human OPN in serum, plasma, cell culture supernatants and urine.
免疫原
Recombinant Human OPN
应用
For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
生化/生理作用
Osteopontin (OPN) is a secreted glycoprotein and is assumed to be associated with various cellular processes such as adhesion, migration, and biomineralization in diverse tissues. Osteopontin acts as a ligand to αvβ3 integrin and possibly other receptors.[3] In addition to its involvement in mineralized matrix formation, osteopontin can also function as a cytokine that stimulates the release of IFNγ (interferon γ) and IL-12 (interleukin 12), while inhibiting the production of IL-10. Osteopontin is involved in inflammation and also regulates immunity against infectious diseases. It also co-stimulates T cell proliferation.[4] Osteopontin has proinflammatory functions and is associated with multiple sclerosis.[5] It participates in inflammation in Crohn′s Disease.[6] Osteopontin plays a crucial role in bone remodelling and retards ectopic calcification by inhibiting the formation of hydroxyapatite. OPN is thought to prevent renal stone formation by suppressing nucleation, growth and aggregation of calcium oxalate crystals.[7]
其他说明
A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.
Please type the word sample in the text box provided for lot number.
警示用语：
Warning
危险声明
预防措施声明
危险分类
Met. Corr. 1
储存分类代码
8A - Combustible corrosive hazardous materials
法规信息
新产品
EFFECT OF MITRAL VALVE SURGERY FOR MITRAL REGURGITATION ON SERUM OSTEOPONTIN LEVELS
Seddik M, et al.
Al-Azhar Assiut Medical Journal, 13(3), 1-1 (2015)
Octavio Gamaliel Aztatzi-Aguilar et al.
PloS one, 16(3), e0249057-e0249057 (2021-03-26)
Osteopontin (OPN) is a protein involved in inflammatory illnesses such as fibrosis and cancer; its overexpression in cardiovascular diseases promotes the biomineralization of blood vessels and other soft tissues. Moreover, there is an active component of oxidative stress related with
Can Osteopontin Be Considered a Biomarker for Endometriosis?
Albu D R, et al.
Revista de Chimie (Bucharest, Romania), 13(3), 1-1 (2017)
Osteopontin, a protein with cytokine-like properties, is associated with inflammation in Crohn's disease.
Agnholt J, et al.
Scandinavian Journal of Immunology, 65, 453-460 (2007)
Identification of an IL-27/osteopontin axis in dendritic cells and its modulation by IFN-gamma limits IL-17-mediated autoimmune inflammation.
Murugaiyan G, et al.
Proceedings of the National Academy of Sciences of the USA, 107, 11495-11500 (2010)
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