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种属反应性
human
包装
kit of 96 wells (12 strips x 8 wells)
技术
ELISA: suitable
capture ELISA: suitable
输入
sample type urine
sample type plasma
sample type cell culture supernatant(s)
sample type serum
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 1 pg/mL
standard curve range: 1.37-1000 pg/mL
检测方法
colorimetric
运输
wet ice
储存温度
−20°C
基因信息
human ... OSM(5008)
一般描述
Oncostatin M (OSM) is a multifunctional hematopoietic cytokine that belongs to the interleukin-6 (IL-6) cytokine family. Human OSM is produced by activated T lymphocytes and monocytes mainly during inflammatory disorders. OSM acts as a cell growth modulator. In addition, it also participates in low-density lipoprotein (LDL) receptor upregulation and induction of hematopoietic factors. OSM contributes to the inflammatory process, autoimmunity, and immunopathogenesis of cancers.
免疫原
Recombinant Human OSM
应用
The Human Oncostatin M (OSM) ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human Oncostatin M in serum, plasma, cell culture supernatants, and urine.
其他说明
A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.
Please type the word sample in the text box provided for lot number.
试剂盒组分也可单独购买
产品编号
说明
化学品安全说明书
警示用语：
Warning
危险声明
预防措施声明
危险分类
Met. Corr. 1
储存分类代码
8A - Combustible corrosive hazardous materials
法规信息
常规特殊物品
Y Ma et al.
Nucleic acids research, 27(23), 4649-4657 (1999-11-11)
Oncostatin M (OSM), an IL-6 subfamily cytokine, inhibits proliferation and causes morphological changes in many tumor cell lines. GM-CSF, phorbol-12-myristate-13-acetate (PMA), and lipopolysaccharide (LPS) induce OSM expression. To investigate the mechanisms governing OSM promoter activity, we have cloned and partially
Oncostatin M: A mysterious cytokine in cancers.
Masjedi, et al.
International Immunopharmacology, 90, 107158-107158 (2021)
A Grenier et al.
Blood, 93(4), 1413-1421 (1999-02-09)
Oncostatin M (OSM) is an interleukin-6 (IL-6) family cytokine known in particular to induce the synthesis of acute-phase proteins by hepatocytes. Because human polymorphonuclear neutrophils (PMN) can secrete numerous cytokines, the potential production of OSM by PMN was investigated. Highly
Pulmonary expression of oncostatin M (OSM) promotes inducible BALT formation independently of IL-6, despite a role for IL-6 in OSM-driven pulmonary inflammation.
Botelho FM
Journal of Immunology, 191, 1453-1464 (2013)
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