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种属反应性
mouse, rat, human
包装
kit of 96 wells (12 strips x 8 wells)
技术
ELISA: suitable
enzyme immunoassay: suitable
输入
sample type serum
sample type culture supernatant(s)
sample type plasma
sample type cell lysate
assay range
inter-assay cv: <15%
intra-assay cv: <10%
sensitivity: 0.125 pg/mL
standard curve range: 0.1–1000 pg/mL
检测方法
colorimetric
运输
wet ice
储存温度
−20°C
基因信息
human ... GIP(2695)
一般描述
Glucose-dependent insulinotropic polypeptide (GIP) is a 42-amino acid gastrointestinal regulatory peptide, expressed in K cells of the small intestine and in cells of the submandibular salivary gland.
免疫原
Gastric Inhibitory Peptide (GIP), synthetic peptide
应用
Gastric inhibitory peptide has been used in enzyme immunoassay.
生化/生理作用
In the presence of glucose, glucose-dependent insulinotropic polypeptide (GIP) induces insulin secretion. It acts as an antagonist of the human GIP receptor. Aberrations in GIP are associated with visceral fat accumulation.
Tao Hao et al.
International journal of molecular medicine, 39(4), 1029-1036 (2017-03-16)
Long-term exposure to a high-fat diet (HFD) causes glucotoxicity and lipotoxicity in islet β cells and leads to the development of metabolic dysfunctions. Reductions in pancreatic and duodenal homeobox-1 (PDX-1) expression have been shown to induce type 2 diabetes mellitus by causing impairments to
Incretin hormones receptor signaling plays the key role in antidiabetic potential of PTY-2 against STZ-induced pancreatitis.
Srivastava S, et al.
Biomedicine and Pharmacotherapy, 97, 330-338 (2018)
Common variants of GIP are associated with visceral fat accumulation in Japanese adults.
Nakayama K, et al.
American Journal of Physiology: Gastrointestinal and Liver Physiology, 307(11), G1108-G1114 (2014)
Shivani Srivastava et al.
Advanced pharmaceutical bulletin, 9(2), 325-330 (2019-08-06)
Purpose: Basically insulin is known to be secreted by β cells of the pancreas. Recently, it has also been found to be produced and expressed by intestinal epithelial cells with the help of L cells secreting glucagon like peptide 1
Shivani Srivastava et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 106, 472-482 (2018-07-11)
To determine the histopathological and molecular changes in β-cells at different time intervals following streptozotocin (STZ)-induced diabetes. STZ (65 mg/kg body weight) was given to overnight fasted rats that were sacrificed after 1, 3, and 10 days of injection. Changes in
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