种属反应性
human, rat, mouse
包装
kit of 96 wells (12 strips x 8 wells)
技术
ELISA: suitable
enzyme immunoassay: suitable
输入
sample type cell lysate
sample type plasma
sample type serum
sample type culture supernatant(s)
assay range
inter-assay cv: <15%
intra-assay cv: <10%
sensitivity: 1.17 pg/mL
standard curve range: 0.1–1000 pg/mL
检测方法
colorimetric
运输
wet ice
储存温度
−20°C
基因信息
human ... GCG(2641)
一般描述
GLP-1 酶联免疫分析 (EIA) 试剂盒是基于竞争性酶联免疫分析原理的体外定量检测 GLP-1 肽的方法。
免疫原
胰高血糖素样肽 1 (GLP-1)，合成肽
应用
仅供研究使用。不用于诊断操作。
生化/生理作用
胰高血糖素样肽 I (GLP1) 通过诱导胰岛素分泌和抑制胰高血糖素的分泌来控制葡萄糖的代谢。对印度尼西亚人群的研究显示，这种蛋白水平的降低与 2 类型糖尿病易感性增加有关。这种激素的血浆水平也显示与收缩压和舒张压水平显著相关。
Ai-Jun Li et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 310(8), R724-R732 (2016-01-23)
Mercaptoacetate (MA) is an orexigenic agent reported to block fatty acid (FA) oxidation. Recently, however, we reported evidence from isolated nodose ganglion neurons that MA antagonizes the G protein-coupled long- and medium-chain FA receptor GPR40. GPR40 mediates FA-induced secretion of
Maria F Fernandes et al.
International journal of molecular sciences, 23(8) (2022-04-24)
Glucagon-like peptide-1 (GLP-1) potentiates glucose-stimulated insulin secretion (GSIS). While dozens of compounds stimulate GLP-1 secretion, few inhibit. Reduced GLP-1 secretion and impaired GSIS occur in chronic inflammation. Lysophosphatidic acids (LPAs) are bioactive phospholipids elevated in inflammation. The aim of this
Mercaptoacetate blocks fatty acid-induced GLP-1 secretion in male rats by directly antagonizing GPR40 fatty acid receptors
Li AJ, et al.
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 310(8), R724-R732 (2016)
Snehal N Chaudhari et al.
Nature chemical biology, 17(1), 20-29 (2020-08-05)
Bariatric surgery, the most effective treatment for obesity and type 2 diabetes, is associated with increased levels of the incretin hormone glucagon-like peptide-1 (GLP-1) and changes in levels of circulating bile acids. The levels of individual bile acids in the
Enteroendocrine cells switch hormone expression along the crypt-to-villus BMP signalling gradient
Beumer J, et al.
Nature Cell Biology, 20(8), 909-909 (2018)
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