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安全信息

R8875

Sigma-Aldrich

鱼藤酮

≥95% (HPLC), powder, NADH-CoQ reductase inhibitor

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100 μG
¥4,622.99

¥4,622.99

预计发货时间2025年5月12日详情

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100 μG
¥4,622.99

About This Item

经验公式（希尔记法）:
C23H22O6
CAS号:
83-79-4
分子量:
394.42
Beilstein:
6773081
EC 号:
201-501-9
MDL编号:
MFCD09025614
UNSPSC代码:
12352202
PubChem化学物质编号:
24278683
NACRES:
NA.77

¥4,622.99

预计发货时间2025年5月12日详情

获取大包装报价

产品名称

鱼藤酮, ≥95%

质量水平

200

方案

≥95%

沸点

210-220 °C/0.5 mmHg (lit.)

mp

159-164 °C (lit.)

SMILES字符串

COc1cc2OCC3Oc4c5C[C@@H](Oc5ccc4C(=O)C3c2cc1OC)C(C)=C

InChI

1S/C23H22O6/c1-11(2)16-8-14-15(28-16)6-5-12-22(24)21-13-7-18(25-3)19(26-4)9-17(13)27-10-20(21)29-23(12)14/h5-7,9,16,20-21H,1,8,10H2,2-4H3/t16-,20-,21+/m1/s1

InChI key

JUVIOZPCNVVQFO-HBGVWJBISA-N

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SAB5600247SAB4502185HPA004751
Anti-Progesterone Receptor A/B Antibody, clone 488/H3 clone 488/H3, from mouse

MABS1235

Anti-Progesterone Receptor A/B Antibody, clone 488/H3

Anti-PR (Progesterone Receptor) antibody, Rabbit monoclonal recombinant, expressed in HEK 293 cells, clone RM357, purified immunoglobulin

SAB5600247

Anti-PR (Progesterone Receptor) antibody, Rabbit monoclonal

Anti-Progesterone Receptor antibody produced in rabbit affinity isolated antibody

SAB4502185

Anti-Progesterone Receptor antibody produced in rabbit

Anti-PGR antibody produced in rabbit Ab1, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

HPA004751

Anti-PGR antibody produced in rabbit

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

Gene Information

human ... PGR(5241)

Gene Information

human ... PGR(5241)

Gene Information

human ... PGR(5241)

Gene Information

human ... PGR(5241)

clone

488/H3, monoclonal

clone

RM357, monoclonal, recombinant monoclonal

clone

polyclonal

clone

polyclonal

biological source

mouse

biological source

-

biological source

rabbit

biological source

rabbit

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

100

一般描述

鱼藤酮属于类视黄醇家族。它天然存在于豆科植物中，并被认为具有细胞毒性。它常被用作杀虫剂。[1]

应用

鱼藤酮已用于：
  • 研究其对细胞增殖的影响[2]
  • 检测分离的大鼠前脑线粒体中细胞活性氧族[3]的产生[4]
  • 测定线粒体酶活[5]

生化/生理作用

线粒体电子转运抑制剂。
鱼藤酮是烟酰胺腺嘌呤二核苷酸（NADH）：泛醌氧化还原酶线粒体电子传递的一种抑制剂。它能够很容易的通过节肢动物的外骨骼被吸收，但皮肤或哺乳动物的胃肠道的吸收则不佳。鱼藤酮作为一种神经毒素能产生帕金森样症状，从而作为一种动物模型用于作为病因和干预措施的研究。鱼藤酮的主要作用机制是通过抑制线粒体复合物Ⅰ造成氧化应激和氧化损伤。由于鱼藤酮的亲脂性，它可以渗入大脑，结合并抑制线粒体电子传递链(ETC)中的复合物Ⅰ。

制备说明

本品可以0.5 mg/ml溶于DMSO。其他信源表明它在DMSO的溶解度可达100 mM，但未经验证。

其他说明

2024年CiteAb奖——成功的帕金森研究供应商(2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research)

象形图

Skull and crossbonesEnvironment
GHS06,GHS09

警示用语：

Danger

危险分类

Acute Tox. 1 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

法规信息

农药列管产品
  • 技术规格说明书

    • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number
    MKCX1422
    MKCV4902
    MKCR3217
    MKCQ7558
    MKCQ1329

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    Loss of Sirt1 promotes prostatic intraepithelial neoplasia, reduces mitophagy, and delays PARK2 translocation to mitochondria
    Di SG, et al.
    The American Journal of Pathology, 185(1), 266-279 (2015)
    Jin Bu et al.
    Life sciences, 231, 116581-116581 (2019-06-21)
    The aims of this study were to investigate the effect of colonic electrical stimulation (CES) on delayed colonic transit in Parkinson's disease (PD) model induced by rotenone and its possible mechanisms. Sprague-Dawley male rats were implanted with a pair of
    Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism
    Fendt SM, et al.
    Cancer Research (2013)
    Jun Matsumoto et al.
    Antimicrobial agents and chemotherapy, 52(1), 164-170 (2007-10-24)
    Alveolar echinococcosis, which is due to the massive growth of larval Echinococcus multilocularis, is a life-threatening parasitic zoonosis distributed widely across the northern hemisphere. Commercially available chemotherapeutic compounds have parasitostatic but not parasitocidal effects. Parasitic organisms use various energy metabolic
    Parkinson's Disease and Movement Disorders, 81-81 (2007)
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