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生物来源
Streptomyces hygroscopicus
质量水平
蒸汽压
0.56 hPa ( 20 °C)
检测方案
≥95% (HPLC)
形式
solution
自燃温度
301 °C
浓度
2.5 mg/mL in DMSO (2.74 mM)
颜色
colorless to yellow
抗生素抗菌谱
fungi
yeast
作用机制
enzyme | inhibits
储存温度
−20°C
相关类别
一般描述
Rapamycin is a macrocyclic triene antibiotic possessing potent immunosuppressant and anticancer activity. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. The effectors of mTOR action include 4EBP1 and S6K1.
Rapamycin, an mTOR inhibitor, is derived from Streptomyces hygroscopicus. It can inhibit viral replication. This natural anti-fungal antibiotic is a proven anti-aging agent. Rapamycin significantly inhibits mTORC1 regardless of age.
应用
Rapamycin has been used:
- as a supplement in mTeSR1 medium to culture induced pluripotent stem cell (iPSC) colonies for induction of autophagy signaling
- to treat the Drosophila S2 cells at 65-70% confluence,
- to measure protein synthesis
- to stimulate autophagy in ovarian cancer cells
包装
200uL
其他说明
保存于密闭容器内,置于干燥通风处。惰性气体中保存。是吸湿性的。
雷帕霉素已经过专家审查并被化学探针门户网站所推荐。如需更多信息,请访问化学探针门户网站上的雷帕霉素探针摘要。
雷帕霉素已经过专家审查并被化学探针门户网站所推荐。如需更多信息,请访问化学探针门户网站上的雷帕霉素探针摘要。
WGK
WGK 1
闪点(°F)
188.6 °F
闪点(°C)
87 °C
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
Modulating eIF6 levels unveils the role of translation in ecdysone biosynthesis during Drosophila development
Developmental Biology, 455, 100-111 (2019)
Autophagy-dependent toxicity of amino-functionalized nanoparticles in ovarian cancer cells
Journal of materials chemistry. B, 7, 5376-5391 (2019)
Stem cell research & therapy, 7, 1-1 (2016-01-06)
Multiple sclerosis is a demyelinating disease mostly of autoimmune origin that affects and damages the central nervous system, leading to a disabling condition. The aim of the present study was to investigate whether administration of mesenchymal stem cells from human
Rapamycin for longevity: opinion article
Aging (Albany. NY.), 11, 8048-8048 (2019)
Cell, 161(6), 1413-1424 (2015-06-06)
Proteomics has proved invaluable in generating large-scale quantitative data; however, the development of systems approaches for examining the proteome in vivo has lagged behind. To evaluate protein abundance and localization on a proteome scale, we exploited the yeast GFP-fusion collection
商品
Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
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