生物来源
human
质量水平
重组
expressed in E. coli
形式
liquid
分子量
52 kDa by SDS-PAGE
技术
ELISA: suitable
UniProt登记号
储存温度
−70°C
基因信息
human ... TRIM21(6737)
一般描述
RO-52 (SSA), also called as tripartite motif-containing protein 21 (TRIM21) is a 52 kDa, ubiquitin E3 ligase. It has a N-terminal RING finger domain (Really Interesting New Gene), crucial for ubiquitination functionality. RO-52 (SSA) gene is mapped to human chromosome 11p5.5.
应用
RO-52 (SSA) human has been used:
- as a component of the autoantigen array
- to immobilise protein on the self-assembly monolayer
- in enzyme-linked immunosorbent assays (ELISAs)
生化/生理作用
RO-52 (SSA) is capable of autoubiquitination and uniquitylates p62 protein and regulates redox homeostasis.Patients with Sjogren′s syndrome display elevated levels of anti-Ro/SSA antibodies. RO-52 levels in peripheral blood mononuclear cells (PBMC) contributes to pathogenesis of systemic lupus erythematosus (SLE), systemic autoimmune rheumatic diseases (SARDs), interstitial lung disease (ILD) and connective tissue diseases (CTD). RO-52 is considered as potential target for treating SLE.
Used for the detection and quantification of antibodies to RNPs in rheumatic diseases.
外形
solution contains 20 mM phosphate buffer, 500 mM NaCl, 2M - 3M urea, pH 6.
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
TRIM21 ubiquitylates SQSTM1/p62 and suppresses protein sequestration to regulate redox homeostasis
Pan JA, et al.
Molecular Cell, 61(5), 720-733 (2016)
Accumulation of Antigen-Driven Lymphoproliferations in Complement Receptor 2/CD 21-/low B Cells From Patients With Sjogren's Syndrome
Glauzy S, et al.
Arthritis and Rheumatism, 70(2), 298-307 (2018)
New structural insights into the role of TROVE2 complexes in the on-set and pathogenesis of systemic lupus erythematosus determined by a combination of QCM-D and DPI
Juste-Dolz A, et al.
Analytical and Bioanalytical Chemistry, 1-12 (2018)
Mapping molecular binding by means of conformational dynamics measurements
do Nascimento NM, et al.
Royal Society of Chemistry Advances, 8(2), 867-876 (2018)
The Sjogren?s syndrome-associated autoantigen Ro52 is an E3 ligase that regulates proliferation and cell death
Espinosa A, et al.
Journal of Immunology, 176(10), 6277-6285 (2006)
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