R8279
RG108
≥98% (HPLC), DNA methyltransferase (DMNT) inhibitor, powder
别名:
N-酞酰-L-色氨酸
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关于此项目
经验公式（希尔记法）:
C19H14N2O4
化学文摘社编号:
分子量:
334.33
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
产品名称
RG108, ≥98% (HPLC), powder
SMILES string
OC(=O)[C@H](Cc1c[nH]c2ccccc12)N3C(=O)C4=CCCC=C4C3=O
InChI
1S/C19H16N2O4/c22-17-13-6-1-2-7-14(13)18(23)21(17)16(19(24)25)9-11-10-20-15-8-4-3-5-12(11)15/h3-8,10,16,20H,1-2,9H2,(H,24,25)/t16-/m0/s1
InChI key
LMAZUAXDZRILNJ-INIZCTEOSA-N
assay
≥98% (HPLC)
form
powder
optical activity
[α]/D -250 to -310°, c = 0.5 in methanol
color
yellow
solubility
DMSO: >10 mg/mL
storage temp.
−20°C
Quality Level
Application
RG108可用于：
- 重编程和提高原代多能间充质干细胞 (MMSC) 的可塑性。
- 作为人视网膜色素上皮细胞ARPE-19中的DNA甲基转移酶抑制剂 (DNMTi)。
- 作为C33A2细胞的DNA甲基转移酶抑制剂，检测其对乳头瘤病毒晚期基因表达 (HPV16) 的影响。
Biochem/physiol Actions
RG108是一种DNA甲基转移酶（DMNT）抑制剂。
RG108是一种DNA甲基转移酶（DMNT）抑制剂。它通过DNA去甲基化重新激活肿瘤细胞中的肿瘤抑制基因表达（p16，SFRP1，分泌性卷曲相关蛋白-1和TIMP-3）。RG108还能抑制人肿瘤细胞系（HCT116，NALM-6）增殖并增加培养的倍增时间。
Rg108的细胞毒性低于氮杂胞苷 (5-Aza-dCR)。它介导食道癌细胞 (EC) 的辐射敏感性。RG108是有效的表观遗传调控剂和去甲基化剂。它不会引起细胞毒性，可用于基于人骨髓间充质干细胞 (hBMSC) 的干细胞治疗。它作用于DNA甲基转移酶1的催化结构域。
Features and Benefits
这种化合物是基因调控研究的特色产品。点击此处发现更多特色基因调控产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
General description
RG108是一种非核苷类似物，也称为[2-(1,3-二氧异吲哚啉-2-基)-3-(1H-吲哚-3-基)丙酸。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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