R7385
磷酰二肽 二钠盐
powder, ≥97% (HPLC)
别名:
N-(α-鼠李糖-吡喃糖-氧代-羟基-膦酰基）-Leu-Trp 二钠盐, N-(α-鼠李糖-吡喃糖基-磷-膦）- L -亮氨酰- L -色氨酸 二钠盐
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关于此项目
经验公式（希尔记法）:
C23H32N3Na2O10P
化学文摘社编号:
分子量:
587.47
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
Beilstein/REAXYS Number:
8105669
产品名称
磷酰二肽 二钠盐, ≥97% (HPLC)
Quality Level
InChI
1S/C23H34N3O10P.2Na/c1-11(2)8-16(26-37(33,34)36-23-20(29)19(28)18(27)12(3)35-23)21(30)25-17(22(31)32)9-13-10-24-15-7-5-4-6-14(13)15;;/h4-7,10-12,16-20,23-24,27-29H,8-9H2,1-3H3,(H,25,30)(H,31,32)(H2,26,33,34);;/q;2*+1/p-2/t12-,16-,17-,18-,19+,20+,23-;;/m0../s1
SMILES string
[Na+].[Na+].CC(C)C[C@H](NP([O-])(=O)O[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C([O-])=O
InChI key
OQKHVXFOYFBMDJ-ODIUWQMJSA-L
biological source
Streptomyces sp.
assay
≥97% (HPLC)
form
powder
solubility
H2O: 50 mg/mL
storage temp.
−20°C
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Application
磷酰二肽二钠盐已被用于：
- 作为脑啡肽酶（NEP）抑制剂: β-淀粉样蛋白 (Aβ) 吸收和分解
- 研究其对角蛋白酶活性的影响
- 处理野生型小鼠的原发性小胶质细胞
鉴定为金属内肽酶抑制剂的磷酰胺可将内皮素转化酶鉴定为金属内肽酶。磷酰胺可增加β-淀粉样蛋白的产量，但不会增加淀粉样蛋白的前体蛋白的含量，这表明阿尔茨海默氏病中淀粉样蛋白的异常加工可能是由金属内肽酶进行的。
Biochem/physiol Actions
磷酰二肽可以抑制ZMPSTE24，其是一种膜蛋白锌金属蛋白酶。它能够阻断嗜热菌蛋白酶。
磷酰二肽是嗜热菌蛋白酶和其他金属内肽酶的强效抑制剂。它对哺乳动物脑啡肽酶有强烈的抑制作用，但是不抑制胰蛋白酶、木瓜蛋白酶、胰凝乳蛋白酶或胃蛋白酶。它对胶原酶有微弱的抑制作用。
General description
磷酰二肽[N-(α-吡喃鼠李糖基-氧基羟基膦酰基)-亮氨酸-色氨酸]是多种可溶性锌金属蛋白酶的竞争性抑制剂。磷酰二肽由链霉菌天然产生。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Phosphoramidon inhibits the integral membrane protein zinc metalloprotease ZMPSTE24
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