推荐产品
质量水平
方案
>96% (HPLC)
表单
solid
储存条件
desiccated
颜色
white to tan
溶解性
H2O: >5 mg/mL at ≤60 °C
运输
wet ice
储存温度
2-8°C
SMILES字符串
O.CS(O)(=O)=O.CCOc1ccccc1O[C@@H]([C@H]2CNCCO2)c3ccccc3
InChI
1S/C19H23NO3.CH4O3S.H2O/c1-2-21-16-10-6-7-11-17(16)23-19(15-8-4-3-5-9-15)18-14-20-12-13-22-18;1-5(2,3)4;/h3-11,18-20H,2,12-14H2,1H3;1H3,(H,2,3,4);1H2/t18-,19-;;/m1../s1
InChI key
SZPHEVAYLIVGRC-BAMQSBMESA-N
应用
Reboxetine mesylate hydrate has been used as a selective norepinephrine transport blocker:
- to study its effects on the surge of dopamine in the cortex of mice brain
- to study its anti-immobility effects on the behavior of mice
- to analyze its effects on the probabilistic reversal learning task in rodents
生化/生理作用
Reboxetine exhibits anti-depressant activity.
Reboxetine mesylate hydrate is a selective noradrenaline uptake inhibitor.
特点和优势
This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
Hagar Gelbard-Sagiv et al.
Current biology : CB, 28(14), 2239-2249 (2018-07-10)
An identical sensory stimulus may or may not be incorporated into perceptual experience, depending on the behavioral and cognitive state of the organism. What determines whether a sensory stimulus will be perceived? While different behavioral and cognitive states may share
S Kasper et al.
Expert opinion on pharmacotherapy, 1(4), 771-782 (2001-03-16)
Several treatment approaches are available for treatment of depression. However, reboxetine is the first selective noradrenaline re-uptake inhibitor. Whereas formerly only noradrenaline re-uptake inhibitors with a mixed mechanism of action were available. These included action not only at noradrenergic, but
Jeremy Koppel et al.
Journal of neurochemistry, 148(1), 127-135 (2018-09-22)
In Alzheimer's disease, the phosphorylation of tau is a critical event preceding the formation of neurofibrillary tangles. Previous work exploring the impact of a dopamine blocking antipsychotic on tau phosphorylation in a tau transgenic model suggested that extracellular dopamine may
Charlotte J W Connell et al.
Medicine and science in sports and exercise, 49(9), 1778-1788 (2017-04-30)
Fatigue-induced impairments in the control of eye movements are detectable via reduced eye movement velocity after a bout of prolonged, strenuous exercise. Slower eye movements caused by neural fatigue within the oculomotor system can be prevented by caffeine, and the
J M Kent
Lancet (London, England), 355(9207), 911-918 (2001-02-07)
A major goal of antidepressant development is to improve on preceding drug classes with agents with greater specificity (and therefore fewer unwanted side-effects) and with more rapid onset of antidepressant action. To this end, four antidepressants with significantly distinct pharmacological
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