推荐产品
生物来源
human
质量水平
重组
expressed in E. coli
方案
≥97% (SDS-PAGE)
表单
lyophilized powder
效能
1-5 ng/mL EC50
分子量
7.8-8.7 kDa
包装
pkg of 10 μg
储存条件
avoid repeated freeze/thaw cycles
技术
cell culture | mammalian: suitable
杂质
endotoxin, tested
UniProt登记号
储存温度
−20°C
基因信息
human ... CCL5(6352)
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相关类别
一般描述
Regulated on activation, normal T cell expressed and secreted (RANTES), also known as C-C motif chemokine ligand 5 (CCL5), is encoded by the gene mapped to human chromosome 17. RANTES belongs to the chemokine family of proinflammatory basic polypeptides and is expressed by various hematopoietic and non-hematopoietic cell types involved in homing and migration of effector and memory T cells during acute infections.
生化/生理作用
Regulated on activation, normal T cell expressed and secreted (RANTES) is a chemoattractant towards monocytes, dendritic cells (DCs), memory T cells (CD4+/CD45RO), basophils, and eosinophils. The encoded chemokine protein functions as a ligand for CCR1, CCR3, and CCR5. RANTES inhibits the action of R5 strains of HIV-1 via blocking CCR5 receptor. A variant of RANTES gene is linked with susceptibility to HIV-1 infection and disease progression. Hence, this can be used as a potent biomarker to determine the prognosis of HIV -1 infection.
外形
Lyophilized from a 0.2 μm filtered solution in 35% acetonitrile and 0.1% trifluoroacetic acid containing 0.5 mg bovine serum albumin.
分析说明
The biological activity is tested in culture using Baf/3 cells. Chemotaxis: EC50: 1-5 ng/mL
警示用语：
Danger
危险分类
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
储存分类代码
3 - Flammable liquids
WGK
WGK 2
闪点(°F)
35.6 °F
闪点(°C)
2 °C
法规信息
含少量动物源组分生物产品
危险化学品
常规特殊物品
A role for the chemokine RANTES in regulating CD8 T cell responses during chronic viral infection.
Crawford A
PLoS Pathogens (2011)
RANTES-activated human T lymphocytes. A role for phosphoinositide 3-kinase.
Journal of Immunology (1995)
Frequency of diagnosis of malignant melanoma.
Roth-Moyo L
Canadian Medical Association Journal (1977)
Role of chemokine and cytokine polymorphisms in the progression of HIV-1 disease.
Biochemical and Biophysical Research Communications (2010)
T J Schall et al.
Nature, 347(6294), 669-671 (1990-10-18)
An important process in the immune response is the migration of different populations of lymphocytes at the proper time to sites of antigenic challenge. Although several chemoattractants are known for broad classes of lymphocytes, such as T and B cells
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