推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
种属反应性
rat, mouse, human
浓度
1 mg/mL
技术
western blot: 6.6 μg/mL using HeLa cell extract
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... RAB11A(8766)
mouse ... Rab11a(53869)
rat ... Rab11a(81830)
一般描述
Rab11 (Ras-related protein) has three subtypes -Rab11a, Rab11b, and Rab25. Rab11a (Ras-related protein Rab-11A) belongs to the ras-like small GTP-binding protein superfamily. It is found in nonpolarized cells like fibroblasts and erythroleukemia cells. It is located on human chromosome 15q21.3-q22.31 and on mouse chromosome 9. Rab11a is expressed abundantly.
免疫原
synthetic peptide corresponding to amino acid residues 1-17 from human Rab11. This sequence is completely conserved in human, mouse, and rat and 94% conserved in C. elegans and amphibians.
应用
Anti-Rab11 has been used in western blotting and immunohistochemistry.
生化/生理作用
Rab11a (Ras-related protein Rab-11A) participates in the modulation of basolateral to apical transcytosis. It controls TRPV5/6 (Ca2+-selective members) channel trafficking. It is essential for the production of bile canalicular in WIF-B9 cells (rat hepatoma/human fibroblast hybrid cells).
外形
Solution in phosphate buffered saline containing 1 mg/mL bovine serum albumin and 0.05% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
The Rab11a GTPase controls Toll-like receptor 4-induced activation of interferon regulatory factor-3 on phagosomes
Husebye H, et al.
Immunity, 33(4), 583-596 (2010)
Rab11a and myosin Vb are required for bile canalicular formation in WIF-B9 cells
Wakabayashi Y, et al.
Proceedings of the National Academy of Sciences of the USA, 15087-92, 15087-15092 (2005)
Direct interaction with Rab11a targets the epithelial Ca2+ channels TRPV5 and TRPV6 to the plasma membrane
van de Graaf SF, et al.
Molecular and Cellular Biology, 26(1), 303-312 (2006)
Neutrophil elastase and proteinase 3 trafficking routes in myelomonocytic cells
Kallquist L, et al.
Experimental Cell Research, 316(19), 3182-3196 (2010)
Human rab11a: transcription, chromosome mapping and effect on the expression levels of host GTP-binding proteins
Gromov PS, et al.
Febs Letters, 429(3), 359-364 (1998)
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