质量水平
检测方案
≥95% (HPLC)
形式
powder
技术
HPLC: suitable
颜色
yellow to yellow-orange
mp
56-58 °C (lit.)
运输
dry ice
储存温度
−20°C
SMILES字符串
CC(=C\C=O)/C=C/C=C(C)\C=C\C1=C(C)CCCC1(C)C
InChI
1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8-,17-13+
InChI key
NCYCYZXNIZJOKI-MKOSUFFBSA-N
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应用
9-顺式-视黄醛用于视色素再生。
生化/生理作用
视黄醛、视黄醇和视黄酸是维生素 A 的醛、醇和酸形式。由于脂肪链中的不饱和键，维 A 酸的几何异构体较多。
9-顺式视黄醛是脊椎动物视杆细胞色素的天然配体（生色团）。9-顺式视黄醛用于研究视功能的机制。
9-顺式视黄醛是脊椎动物视杆细胞色素的天然配体（生色团）。9-顺式视黄醛用于研究视功能的机制。
警示用语：
Warning
危险分类
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Skin Irrit. 2
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Vladimir J Kefalov et al.
Neuron, 46(6), 879-890 (2005-06-15)
Retinal rod and cone pigments consist of an apoprotein, opsin, covalently linked to a chromophore, 11-cis retinal. Here we demonstrate that the formation of the covalent bond between opsin and 11-cis retinal is reversible in darkness in amphibian red cones
Ching-Ju Tsai et al.
Science advances, 4(9), eaat7052-eaat7052 (2018-09-27)
Selective coupling of G protein (heterotrimeric guanine nucleotide-binding protein)-coupled receptors (GPCRs) to specific Gα-protein subtypes is critical to transform extracellular signals, carried by natural ligands and clinical drugs, into cellular responses. At the center of this transduction event lies the
L Xu et al.
Current opinion in genetics & development, 9(2), 140-147 (1999-05-14)
The nuclear hormone receptors constitute a large family of transcription factors. The binding of the hormonal ligands induces nuclear receptors to assume a configuration that leads to transcriptional activation. Recent studies of retinoic acid and thyroid hormone receptors revealed that
A Cambrian origin for vertebrate rods
Sabrina A, et al.
eLife, 4 (2015)
QLT091001, a 9-cis-retinal analog, is well-tolerated by retinas of mice with impaired visual cycles.
Tadao Maeda et al.
Investigative ophthalmology & visual science, 54(1), 455-466 (2012-12-20)
Investigate whether retinas of mice with impaired retinal cycles exposed to light or kept in the dark tolerate prolonged high-dose administration of QLT091001, which contains as an active ingredient, the 9-cis-retinal precursor, 9-cis-retinyl acetate. Four- to six-week-old Lrat(-/-) and Rpe65(-/-)
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