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生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
18E4, monoclonal
表单
buffered aqueous solution
分子量
antigen 55-70 kDa
种属反应性
mouse, bovine, human, rat, canine, Xenopus, chicken
技术
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
indirect ELISA: suitable
microarray: suitable
western blot: 1-2 μg/mL using HeLa total cell extract
一般描述
Monoclonal Anti-hnRNP-Q (mouse IgG1) is derived from the 18E4 hybridoma produced by the fusion of murine myeloma cells (SP2/0 cells) and splenocytes from BALB/c mice immunized with recombinant human hnRNP-Q. Heterogeneous nuclear ribonucleoproteins-Q (hnRNP-Q) family of proteins consist of three proteins (Q1, 2, and 3) that are derived by alternative splicing from the same gene.
特异性
The hnRNP-Q and hnRNP-R antibodies share 83% homology.
免疫原
recombinant human hnRNP-Q.
应用
Monoclonal Anti-hnRNP-Q antibody produced in mouse has been used in immunoblotting and immunofluorescence. It may be used in enzyme linked immunosorbent assay (ELISA), immunoprecipitation and immunohistochemistry.
生化/生理作用
Heterogeneous nuclear ribonucleoproteins (hnRNPs) act in several biological activities such as transcription, pre- mRNA processing, cytoplasmic mRNA translation and turnover. These proteins interact with the survival of motor neurons protein (SMN) that is mutated in patients with spinal muscular atrophy (SMA). Immunodepletion of hnRNP-Q proteins and their localization in spliceosomes, indicate their important role in splicing.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
历史批次信息供参考:
Structural determinants of APOBEC3B non-catalytic domain for molecular assembly and catalytic regulation
Xiao X, et al.
Nucleic Acids Research, 45(12), 7494-7506 (2017)
Sung Wook Kim et al.
Cells, 10(12) (2021-12-25)
Protein aggregates of cofilin and actin have been found in neurons under oxygen-glucose deprivation. However, the regulatory mechanism behind the expression of Cfl1 during oxygen-glucose deprivation remains unclear. Here, we found that heterogeneous nuclear ribonucleoproteins (hnRNP) Q and hnRNP A1
SMN interacts with a novel family of hnRNP and spliceosomal proteins
Mourelatos Z, et al.
The Embo Journal, 20(19), 5443-5452 (2001)
A Membraneless Organelle Associated with the Endoplasmic Reticulum Enables 3'UTR-Mediated Protein-Protein Interactions
Ma W and Mayr C
Cell, 175(6), 1492-1506 (2018)
Xiao Xiao et al.
Nucleic acids research, 45(12), 7494-7506 (2017-06-03)
The catalytic activity of human cytidine deaminase APOBEC3B (A3B) has been correlated with kataegic mutational patterns within multiple cancer types. The molecular basis of how the N-terminal non-catalytic CD1 regulates the catalytic activity and consequently, biological function of A3B remains
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