R5279
Anti-Rab9 from rabbit
~1 mg/mL, affinity isolated antibody, buffered aqueous solution
别名:
Anti-Ras-Associated Protein Rab9, Anti-Ras-Related Protein Rab9
产品名称
Anti-Rab9 from rabbit, ~1 mg/mL, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~23 kDa
species reactivity
rat, mouse, human
concentration
~1 mg/mL
technique(s)
indirect immunofluorescence: 5-10 μg/mL using rat NRK and mouse NIH3T3 cells fixed and permeabilized with 3% paraformaldehyde followed by 0.4% saponin
western blot: 5-10 μg/mL using whole extract of human A431 cells
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... RAB9A(9367)
mouse ... Rab9(56382)
rat ... Rab9a(84589)
Application
Anti-Rab9 from rabbit has been used in immunoblotting and immunofluorescence.
Biochem/physiol Actions
Rab9 GTPase is required for the transport of mannose 6-phosphate receptors (MPRs) from endosomes to the trans-Golgi network (TGN). Rab9 GTPase in its GTP bound conformation binds specifically to an effector protein named p40 that stimulates the transport of mannose 6-phosphate receptors (MPRs) from endosomes to the TGN. Rab9 also interacts with the vesicle cargo selection protein TIP47 (tail-interacting protein of 47 kDa). This interaction is required for Rab9 stability on late endosomes. Anti-Rab9 antibodies may be used as a marker for late endosomes.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Rab9 is a member of the Rab family of guanosine triphosphatases (GTPases). Rab9 GTPase is localized predominantly to late endosomes. Rab proteins contain conserved regions involved in guanine nucleotide binding, and hypervariable COOH-terminal domains with a cysteine motif implicated in subcellular targeting.
Immunogen
synthetic peptide corresponding to amino acid residues 188-200 of human Rab9, conjugated to KLH.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
High Resolution Crystal Structure of Human Rab9 GTPase a Novel Antiviral Drug Target
Chen L, et al.
The Journal of Biological Chemistry, 279(38), 40204-40208 (2004)
Rab9 GTPase regulates late endosome size and requires effector interaction for its stability
Ganley IG, et al.
Molecular Biology of the Cell, 15(12), 5420-5430 (2004)
The rab gtpase family
Stenmark H and Olkkonen VM
Genome Biology, 2(5), 3007-3001 (2001)
Small GTP-binding proteins
Takai Y, et al.
Physiological Reviews, 81(1), 153-208 (2001)
E Díaz et al.
The Journal of cell biology, 138(2), 283-290 (1997-07-28)
Rab9 GTPase is required for the transport of mannose 6-phosphate receptors from endosomes to the trans-Golgi network in living cells, and in an in vitro system that reconstitutes this process. We have used the yeast two-hybrid system to identify proteins
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