R4654
Anti-Rab5 antibody produced in rabbit
~1 mg/mL, affinity isolated antibody, buffered aqueous solution
别名:
Anti-Ras-Related Protein Rab5A
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关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
indirect immunofluorescence
western blot
western blot
Species reactivity:
human, mouse, rat
Citations:
15
Technique(s):
indirect immunofluorescence: 5-10 μg/mL using rat NRK and mouse NIH-3T3 cells.
western blot: 2.5-5 μg/mL using whole extract of human A431 cells
western blot: 2.5-5 μg/mL using whole extract of human A431 cells
Uniprot accession no.:
产品名称
Anti-Rab5 antibody produced in rabbit, ~1 mg/mL, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~24 kDa
species reactivity
human, mouse, rat
concentration
~1 mg/mL
technique(s)
indirect immunofluorescence: 5-10 μg/mL using rat NRK and mouse NIH-3T3 cells.
western blot: 2.5-5 μg/mL using whole extract of human A431 cells
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... RAB5A(5868)
mouse ... Rab5a(271457)
rat ... Rab5a(64633)
Application
Anti-Rab5 antibody produced in rabbit has been used in western blotting and immunocytochemistry.
Biochem/physiol Actions
Rab proteins are members of small GTPases control the exocytosis and endocytosis and regulate vesicular transport. Rab5 regulates endocytic pathway in mammalian cells and an activator of autophagy. It mediates macroautophagy of cells expressing aggregates of mutant Huntingtin protein.
Rab5a is essential for epidermal growth factor (EGF)-mediated EGF receptor degradation. Overexpression of Rab5a is associated with the development of variety of cancers such as breast cancer, lung cancer, hepatocellular carcinoma (HCC) and ovarian cancer.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Ras related protein consists of three isoforms such as Rab5a, Rab5b and Rab5c. Rab5a is encoded by the gene mapped to human chromosome 3p24.3. This gene codes for 23.66 kDa Rab5a protein.
Immunogen
synthetic peptide corresponding to amino acid residues 176-188 of human Rab5 with C-terminal added cysteine, conjugated to KLH.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Site-specific monoubiquitination downregulates Rab5 by disrupting effector binding and guanine nucleotide conversion
Shin D, et al.
eLife, 6, e29154-e29154 (2017)
J Somsel Rodman et al.
Journal of cell science, 113 Pt 2, 183-192 (2000-01-14)
Endocytosis is characterized by vesicular transport along numerous pathways. Common steps in each pathway include membrane budding to form vesicles, transport to a particular destination, and ultimately docking and fusion with the target membrane. Specificity of vesicle targeting is rendered
Lysosomal network proteins as potential novel CSF biomarkers for Alzheimer?s disease
Armstrong A, et al.
Neuromolecular Medicine, 16(1), 150-160 (2014)
Rab5a promotes the migration and invasion of hepatocellular carcinoma by up-regulating Cdc42
Yang X, et al.
International Journal of Clinical and Experimental Pathology, 11(1), 224-231 (2018)
Maisel J Caliva et al.
Scientific reports, 11(1), 19830-19830 (2021-10-08)
Endosomal trafficking of cell surface receptors is essential to their function. Integrins are transmembrane receptors that integrate adhesion to the extracellular matrix with engagement of the cytoskeleton. Ligated integrins mediate diverse signals that regulate matrix assembly, cell survival, cell morphology
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