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Merck
CN
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安全信息

R4408

Sigma-Aldrich

氯霉素

Ready Made Solution, 100 mg/mL in ethanol: isopropanol (95:5), ≥98% (HPLC)

别名:

D-(-)-苏-2,2-二氯-N-[β-羟基-α−（羟甲基）-β-（4-硝基苯基）乙基]乙酰胺, D-(-)-苏-2-二氯乙酰胺基-1-（4-硝基苯基）-1,3-丙二醇, D-苏-2,2-二氯-N-[β-羟基-α-（羟甲基）-4-硝基苯乙基]乙酰胺

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About This Item

UNSPSC代码:
51101500
NACRES:
NA.85

质量水平

200

检测方案

≥98% (HPLC)

形式

solution

浓度

100 mg/mL in ethanol: isopropanol (95:5)

抗生素抗菌谱

Gram-negative bacteria
Gram-positive bacteria

作用机制

protein synthesis | interferes

运输

dry ice

储存温度

−20°C

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相关类别

应用

氯霉素是一种合成抗生素，从委内瑞拉链霉菌菌株中分离出来。 它通常以10-20 μg/mL的浓度用于分子生物学应用中的细菌选择，并作为含有氯霉素抗性基因的转化细胞的选择剂。

生化/生理作用

作用机制：氯霉素通过与50S核糖体亚基结合并阻止氨酰基tRNA附着于核糖体来阻断肽基转移酶步骤，从而抑制细菌蛋白质的合成。 它还抑制线粒体和叶绿体蛋白的合成以及（p）ppGpp的核糖体形成，从而抑制rRNA的转录。

耐药性机制：使用氯霉素乙酰转移酶会使产物乙酰化并使其失活。

抗菌谱：这是一种针对革兰氏阳性和革兰氏阴性细菌的广谱抗生素，主要用于眼科和兽医目的。

包装

10ml

制备说明

该产品是在乙醇：异丙醇（95:5）中制备的100 mg/mL溶液。 干冰运输，-20℃下保存。

其他说明

保存于密闭容器内，置于干燥通风处。打开的容器必须小心地重新密封，并保持直立以防止泄漏。储存等级（TRGS 510）：易燃液体“）

警示用语：

Danger

危险分类

Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Repr. 2

WGK

WGK 3

闪点(°F)

closed cup

闪点(°C)

closed cup

法规信息

危险化学品

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