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R3652

Sigma-Aldrich

Raf-1 Protein Kinase human

recombinant, expressed in E. coli, ~20 units/mg protein

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About This Item

MDL编号:
MFCD04041081
UNSPSC代码:
12352204
NACRES:
NA.54

重组

expressed in E. coli

质量水平

200

表单

solution

比活

~20 units/mg protein

分子量

74 kDa

UniProt登记号

P04049

相关疾病

cancer

运输

dry ice

储存温度

−70°C

基因信息

human ... RAF1(5894)

应用

Raf-1 is a serine/threonine protein kinase which is involved in the MAPK signal transduction pathway, a pathway that is involved in the development and progression of cancer. Raf-1 kinases are used to study potential cancer treatments as well as the responses to cancer treatments .

生化/生理作用

Raf-1 activates the protein kinases MEK1 and MEK2. MEK1 and MEK2 are phosphorylated to activate protein kinases ERK1 and ERK2. Activated ERKs play an important role in cell division, apoptosis, cell differentiation, and cell migration .

单位定义

One unit will activate MEK B substrate by 10% per min at pH 7.0 at 30 °C.

外形

Solution in 50 mM Tris-HCl, pH 7.0 buffer containing 14 mM β-mercaptoethanol, 1 mM benzamidine, 0.1 mM PMSF, 1 mM EDTA, and 10% glycerol.

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H317

危险分类

Skin Sens. 1

储存分类代码

10 - Combustible liquids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
SLBZ8348
SLBW3424
SLBQ2587V
031M1842
063K0328

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  1. How does the storage temperature relate to shipping conditions?

    The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment. See Shipping and Storage for more information.

  2. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  3. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  4. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  5. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  6. Does Product R3652, Raf-1 Protein Kinase human, contain a GST tag?

    Yes. Product R3652, Raf-1 Protein Kinase human, contains a GST tag on the amino terminal end. 

  7. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Liane M McGlynn et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 15(4), 1487-1495 (2009-02-21)
The expression and activation of the Ras/Raf-1/mitogen-activated protein kinase (MAPK) pathway plays an important role in the development and progression of cancer, and may influence response to treatments such as tamoxifen and chemotherapy. In this study we investigated whether the
Raf kinase as a target for anticancer therapeutics
Sridhar SS, Hedley D, et al.
Clinical Cancer Research, 4, 677-685 (2005)

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