¥655.91
目录价¥948.04节省 31%国内现货，预计发货时间2025年4月27日详情
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此商品 | R1158 | R6513 | R5503 |
|---|---|---|---|
| biological source human placenta | biological source - | biological source - | biological source bovine pancreas |
| Quality Level 200 | Quality Level 300 | Quality Level 300 | Quality Level 300 |
| form buffered aqueous solution | form buffered aqueous solution | form lyophilized | form lyophilized powder |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| shipped in dry ice | shipped in dry ice | shipped in - | shipped in - |
| mol wt ~50 kDa | mol wt ~50 kDa | mol wt 13.7 kDa, ~13,700 | mol wt ~13,700 |
一般描述
核糖核酸酶抑制剂通过形成紧密非共价的1:1复合物抑制RNase活性。 来源于人胎盘。 抑制RNA酶A、B和C。不抑制RNA酶H、1、T1、S1核酸酶、SP6、T7 RNA聚合酶、T3 RNA聚合酶、AMV逆转录酶、M-MLV逆转录酶或Taq聚合酶。 抑制剂可通过苯酚萃取或加热至65℃ 10分钟去除。
应用
用于体外抑制核糖核酸酶，包括cDNA合成、RT-PCR、及体外转录和翻译等实验。
适用于
- 体外抑制核糖核酸酶
- cDNA合成
- RT-PCR
- 体外转录和翻译
生化/生理作用
通过形成紧密非共价的1:1复合体抑制RNase活性。
通过形成紧密非共价的1:1复合体抑制RNase活性。也可抑制血管生成素，一种与RNase A同源的新生血管促进因子。
组分
核糖核酸酶抑制剂溶液，含20 mM HEPES-KOH( pH 7.6)、50 mM KCl、8 mM DTT和50%甘油。
其他说明
这种RNA酶活性抑制剂分离自人类胎盘，为甘油缓冲水溶液形式。
溶液，pH 7.6，含50%甘油、20 mM HEPES-KOH、50 mM KCl和8 mM DTT
单位定义
一个单位的抑制剂可将一个胞苷2′:3′-环单磷酸盐体系中5 ng核糖核酸酶A的活性降低50%。
外形
溶液，pH 7.6，含50%甘油、20 mM HEPES-KOH、50 mM KCl和8 mM DTT
储存分类代码
12 - Non Combustible Liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
高风险级别生物产品--人源产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Mariona Estapé Senti et al.
Journal of controlled release : official journal of the Controlled Release Society, 341, 475-486 (2021-12-11)
PEGylation of lipid-based nanoparticles and other nanocarriers is widely used to increase their stability and plasma half-life. However, either pre-existing or de novo formed anti-PEG antibodies can induce hypersensitivity reactions and accelerated blood clearance through binding to the nanoparticle surfaces
Sabahattin Kaymakoglu et al.
Antimicrobial agents and chemotherapy, 49(3), 1135-1138 (2005-02-25)
The success of alpha interferon (IFN-alpha) monotherapy for the treatment of chronic hepatitis D is very limited. In this study, the efficacy of IFN-alpha and ribavirin combination therapy for chronic hepatitis D was investigated. Nineteen patients (15 males; mean age
Ribonuclease inhibitor from human placenta: interaction with derivatives of ribonuclease A.
P Blackburn et al.
The Journal of biological chemistry, 254(24), 12488-12493 (1979-12-25)
Michal Mikula et al.
The Journal of biological chemistry, 286(11), 9763-9775 (2011-01-15)
Components of the ERK cascade are recruited to genes, but it remains unknown how they are regulated at these sites. The RNA-binding protein heterogeneous nuclear ribonucleoprotein (hnRNP) K interacts with kinases and is found along genes including the mitogen-inducible early
Malia Su-Qin Murphy et al.
American journal of obstetrics and gynecology, 213(3), 367-367 (2015-05-20)
Preeclampsia (PE) is a hypertensive disorder of pregnancy characterized by widespread maternal endothelial dysfunction. Although clinical signs subside following delivery, long-term risks associated with PE include hypertension, stroke, and cardiovascular disease. MicroRNAs (miRNAs) are emerging as critical regulators of biological
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