重组
expressed in E. coli
质量水平
表单
buffered aqueous glycerol solution
UniProt登记号
运输
dry ice
储存温度
−20°C
基因信息
human ... RALB(5899)
应用
Can be used as a control in immunoblotting and in protein binding assays.
生化/生理作用
Ral B (21 kDa, native), a member of the Ras-like GTP binding protein family, is a crucial link in intracellular signaling cascades.
Ral B has been implicated in invasion and metastasis of human cancer cells. Reports have shown that depletion of Ral B by siRNA results in significantly reduced migration rates of tumor cells, while constitutively active Ral B promoted migration.
其他说明
GST-tagged Ras-like fusion protein
外形
Supplied as a solution in 50 mM Tris, pH 7.5, containing 150 mM sodium chloride, 10 mM magnesium chloride, 1 mM DTT, and 10% glycerol.
储存分类代码
10 - Combustible liquids
法规信息
新产品
Gary Oxford et al.
Cancer research, 65(16), 7111-7120 (2005-08-17)
The Ral family of small G proteins has been implicated in tumorigenesis, invasion, and metastasis. However, little emphasis has been placed on clarifying the individual roles of the two Ral proteins, RalA and RalB, in these processes in view of
Y Takai et al.
Physiological reviews, 81(1), 153-208 (2001-01-12)
Small GTP-binding proteins (G proteins) exist in eukaryotes from yeast to human and constitute a superfamily consisting of more than 100 members. This superfamily is structurally classified into at least five families: the Ras, Rho, Rab, Sar1/Arf, and Ran families.
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