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Merck
CN

R1908

Sigma-Aldrich

Remifentanil hydrochloride

≥97% (HPLC), powder

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别名:
3-[methoxycarbonyl-4-[(1-oxopropyl)phenylamino]1-piperidine]propanoic acid methyl ester hydrochloride, GI-87084B, Remifentanyl, Ultiva
经验公式(希尔记法):
C20H28N2O5·HCl
分子量:
412.91
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:

质量水平

检测方案

≥97% (HPLC)

形式

powder

药品控制

USDEA Schedule II; regulated under CDSA - not available from Sigma-Aldrich Canada; estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)

储存条件

desiccated

颜色

white to off-white

溶解性

H2O: ≥20 mg/mL

储存温度

2-8°C

SMILES字符串

O=C(CC)N(C1(CCN(CCC(OC)=O)CC1)C(OC)=O)C2=CC=CC=C2.[H]Cl

InChI

1S/C20H28N2O5.ClH/c1-4-17(23)22(16-8-6-5-7-9-16)20(19(25)27-3)11-14-21(15-12-20)13-10-18(24)26-2;/h5-9H,4,10-15H2,1-3H3;1H

InChI key

WFBMIPUMYUHANP-UHFFFAOYSA-N

基因信息

human ... OPRM1(4988)

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生化/生理作用

Remifentanil hydrochloride is a mu opioid receptor agonist, anesthetic, and analgesic compound. Remifentanil was developed as an ultra-short-acting mu opioid receptor agonist with improved pharmacodynamic properties.

特点和优势

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

象形图

Health hazard

警示用语:

Warning

危险声明

危险分类

STOT SE 2

靶器官

Respiratory system

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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Tor D Wager et al.
The New England journal of medicine, 368(15), 1388-1397 (2013-04-12)
Persistent pain is measured by means of self-report, the sole reliance on which hampers diagnosis and treatment. Functional magnetic resonance imaging (fMRI) holds promise for identifying objective measures of pain, but brain measures that are sensitive and specific to physical
M Gruenewald et al.
British journal of anaesthesia, 110(6), 1024-1030 (2013-03-09)
Measurement of the balance between nociception and anti-nociception during anaesthesia is challenging and not yet clinically established. The Surgical pleth index (SPI), derived from photoplethysmography, was proposed as a surrogate measure of nociception. Recently, the analgesia nociception index (ANI) derived
A Harsten et al.
British journal of anaesthesia, 111(3), 391-399 (2013-04-13)
This study was undertaken to compare the effects of general anaesthesia (GA) and spinal anaesthesia (SA) on the need for postoperative hospitalization and early postoperative comfort in patients undergoing fast-track total knee arthroplasty (TKA). One hundred and twenty subjects were
Arne Kristian Skulberg et al.
European journal of clinical pharmacology, 74(7), 873-883 (2018-03-24)
This study aimed to develop a model for pharmacodynamic and pharmacokinetic studies of naloxone antagonism under steady-state opioid agonism and to compare a high-concentration/low-volume intranasal naloxone formulation 8 mg/ml to intramuscular 0.8 mg. Two-way crossover in 12 healthy volunteers receiving naloxone while
N A Pedersen et al.
Acta anaesthesiologica Scandinavica, 57(8), 988-995 (2013-07-10)
Magnetic resonance imaging (MRI) of children is generally performed under sedation or with general anaesthesia (GA), but the ideal regimen has not been found. The aim of this study was to see if propofol-remifentanil would be a suitable alternative for

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