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一般描述
Receptor interacting serine/threonine kinase 2 (RIPK2) or RICK is a serine/threonine kinase.[1] It contains a kinase domain at the amino-terminal, an intermediate domain and a caspase activation and recruitment domain (CARD) at the carboxy-terminal.[2] The gene encoding RIPK2 is localized on human chromosome 8q21.3.[3]
生化/生理作用
Receptor interacting serine/threonine kinase 2 (RIPK2) or RICK is activated during innate immune responses and acts as a scaffold for downstream effectors.[4] It functions in nuclear factor-κB (NFκB) activation pathways.[1] The protein also has roles in toll-like receptor (TLR)-signaling pathways and in the production of inflammatory cytokines.[5]
外形
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
法律信息
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
Knockdown of receptor-interacting serine/threonine protein kinase-2 (RIPK2) affects EMT-associated gene expression in human hepatoma cells.
Wu S
Anticancer Research, 3775-3783 (2012)
Structures of the inactive and active states of RIP2 kinase inform on the mechanism of activation.
Pellegrini E
PLoS ONE (2017)
M Thome et al.
Current biology : CB, 8(15), 885-888 (1998-08-26)
Members of the tumor necrosis factor receptor (TNFR) superfamily have an important role in the induction of cellular signals resulting in cell growth, differentiation and death. TNFR-1 recruits and assembles a signaling complex containing a number of death domain (DD)-containing
Receptor-interacting protein 2 (RIP2) gene polymorphisms are associated with increased risk of subclinical atherosclerosis and clinical and metabolic parameters. The Genetics of Atherosclerotic Disease (GEA) Mexican study.
Posadas S
Experimental and Molecular Pathology (2017)
Primary urethral clear-cell adenocarcinoma: comprehensive analysis by surgical pathology, cytopathology, and next-generation sequencing.
Rohit Mehra
The American Journal of Pathology (2014)
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