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Merck
CN

R1406

Sigma-Aldrich

RIPK2 (1-299),活性,GST 标记 人

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

别名:

CARD3, CARDIAK, RICK, RIP2

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25 μL
CN¥2,257.75
100 μL
CN¥5,169.41
200 μL
CN¥8,231.20

CN¥2,257.75


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25 μL
CN¥2,257.75
100 μL
CN¥5,169.41
200 μL
CN¥8,231.20

About This Item

UNSPSC代码:
51111800
NACRES:
NA.32

CN¥2,257.75


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重组

expressed in baculovirus infected Sf9 cells

质量水平

产品线

PRECISIO® Kinase

方案

≥70% (SDS-PAGE)

表单

buffered aqueous glycerol solution

比活

17-23 nmol/min·mg

分子量

~59 kDa

UniProt登记号

运输

dry ice

储存温度

−70°C

一般描述

Receptor interacting serine/threonine kinase 2 (RIPK2) or RICK is a serine/threonine kinase.[1] It contains a kinase domain at the amino-terminal, an intermediate domain and a caspase activation and recruitment domain (CARD) at the carboxy-terminal.[2] The gene encoding RIPK2 is localized on human chromosome 8q21.3.[3]

生化/生理作用

Receptor interacting serine/threonine kinase 2 (RIPK2) or RICK is activated during innate immune responses and acts as a scaffold for downstream effectors.[4] It functions in nuclear factor-κB (NFκB) activation pathways.[1] The protein also has roles in toll-like receptor (TLR)-signaling pathways and in the production of inflammatory cytokines.[5]

外形

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

法律信息

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

10 - Combustible liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Knockdown of receptor-interacting serine/threonine protein kinase-2 (RIPK2) affects EMT-associated gene expression in human hepatoma cells.
Wu S
Anticancer Research, 3775-3783 (2012)
M Thome et al.
Current biology : CB, 8(15), 885-888 (1998-08-26)
Members of the tumor necrosis factor receptor (TNFR) superfamily have an important role in the induction of cellular signals resulting in cell growth, differentiation and death. TNFR-1 recruits and assembles a signaling complex containing a number of death domain (DD)-containing
Receptor-interacting protein 2 (RIP2) gene polymorphisms are associated with increased risk of subclinical atherosclerosis and clinical and metabolic parameters. The Genetics of Atherosclerotic Disease (GEA) Mexican study.
Posadas S
Experimental and Molecular Pathology (2017)
Structures of the inactive and active states of RIP2 kinase inform on the mechanism of activation.
Pellegrini E
PLoS ONE (2017)
Primary urethral clear-cell adenocarcinoma: comprehensive analysis by surgical pathology, cytopathology, and next-generation sequencing.
Rohit Mehra
The American Journal of Pathology (2014)

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