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About This Item
经验公式（希尔记法）:
C9H11ClN2O · HCl
CAS号:
分子量:
235.11
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
推荐产品
表单
solid
颜色
white
mp
216-217 °C
溶解性
H2O: soluble
SMILES字符串
Cl.NCCNC(=O)c1ccc(Cl)cc1
InChI
1S/C9H11ClN2O.ClH/c10-8-3-1-7(2-4-8)9(13)12-6-5-11;/h1-4H,5-6,11H2,(H,12,13);1H
InChI key
ARUMZUNJBHSOQQ-UHFFFAOYSA-N
基因信息
human ... MAOB(4129)
生化/生理作用
Selective, reversible, orally-active MAO-B inhibitor which is devoid of indirect sympathomimetic activity.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
Ro 16-6491: a new reversible and highly selective MAO-B inhibitor protects mice from the dopaminergic neurotoxicity of MPTP.
M Da Prada et al.
Advances in neurology, 45, 175-178 (1987-01-01)
A M Cesura et al.
Journal of neurochemistry, 50(4), 1037-1043 (1988-04-01)
[3H]Ro 16-6491 [N-(2-aminoethyl)-p-chlorobenzamide HCl], a reversible "mechanism-based" inhibitor of monoamine oxidase (MAO) type B, binds selectively and with high affinity to the active site of MAO-B in brain and platelet membranes. Under normal conditions, the binding of [3H]Ro 16-6491 is
A M Cesura et al.
Journal of neurochemistry, 48(1), 170-176 (1987-01-01)
The reversible inhibitor of monoamine oxidase type B (MAO-B) [3H]Ro 16-6491 binds specifically and with high affinity to a single population of binding sites in human frontal cortex crude mitochondria and platelet membranes. In both tissues binding equilibrium was reached
E L Mullan et al.
Journal of neural transmission. Supplementum, 41, 307-311 (1994-01-01)
Ro 16-6491 is known to be a potent reversible inhibitor of human brain MAO-B. This compound and several analogues were tested for their effect on bovine liver MAO-B. It was found that in compounds where the amide bond of Ro
Characterization of [3H]Ro 16-6491 binding to digitonin solubilized monoamine oxidase-B and purification of the enzyme from human platelets by affinity chromatography.
A M Cesura et al.
Biochemical pharmacology, 39(1), 216-220 (1990-01-01)
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