生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
antigen 17 kDa
种属反应性
mouse, human, rat
浓度
~1 mg/mL
技术
immunoprecipitation (IP): 5-10 μg using HEK-293T cell lysates
indirect immunofluorescence: 5-10 μg/mL using paraformaldehye-fixed HeLa cells
western blot: 0.5-1 μg/mL using HEK-293T cell extracts
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... RPL26(6154)
mouse ... Rpl26(19941)
rat ... Rpl26(287417)
一般描述
RPL26 (ribosomal protein L26) is located on chromosome 17. It codes for a 145-amino-acid long protein and has four exons. It is present on the large ribosomal subunit.
Ribosomal protein L26 is one of the large ribosomal subunit proteins.
特异性
Anti-Ribosomal Protein L26 (N-terminal) specificallyrecognizes human Ribosomal Protein L26.
免疫原
synthetic peptide corresponding to amino acids 1-17 of human ribosomal protein L26, conjugated to KLH via a C-terminal added cysteine residue. The sequence is conserved in human, rat, and mouse.
应用
Anti-Ribosomal Protein L26 (N-terminal) antibody produced in rabbit has been used in:
- immunoblotting
- immunoprecipitation
- immunostaining
- immunofluorescence
- coimmunoprecipitation analysis
生化/生理作用
RPL26 (ribosomal protein L26) regulates the expression of p73. It plays an important role in translation and stability of ribosomes. RPL26 frameshift mutation can cause several physical abnormalities.
Ribosomal proteins are implicated in mRNA recognition, tRNA recognition and decoding and nuclear export. It was shown together with nucleolin to bind to the 5′ untranslated region of p53 mRNA and to control p53 translation and induction after DNA damage.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
Acute and Chronic Sustained Hypoxia Do Not Substantially Regulate Amyloid-beta Peptide Generation In Vivo
Serrano-PA, et al.
Testing, 12(1), e0170345-e0170345 (2017)
The nuclear mitotic apparatus protein NuMA controls rDNA transcription and mediates the nucleolar stress response in a p53-independent manner
Jayaraman S, et al.
Nucleic Acids Research, 45(20), 11725-11742 (2017)
Mdm2 Regulates p53 mRNA Translation through Inhibitory Interactions with Ribosomal Protein L26
Ofir-RY, et al.
Molecular Cell, 32(2), 180-189 (2008)
Frameshift mutation in p53 regulator RPL26 is associated with multiple physical abnormalities and a specific pre-ribosomal RNA processing defect in diamond-blackfan anemia.
Gazda HT
Human Mutation, 33(7), 1037-1044 (2012)
p73 expression is regulated by ribosomal protein RPL26 through mRNA translation and protein stability
Zhang M, et al.
Oncotarget, 7(48), 78255-78268 (2016)
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