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质量水平
方案
≥98% (HPLC)
表单
powder
旋光性
[α]/D -9 to -12, c = 1 in methanol
储存条件
desiccated
颜色
white to off-white
溶解性
H2O: 5 mg/mL, clear
创始人
AstraZeneca
储存温度
2-8°C
SMILES字符串
O.Cl.CCCN1CCCC[C@H]1C(=O)Nc2c(C)cccc2C
InChI
1S/C17H26N2O.ClH.H2O/c1-4-11-19-12-6-5-10-15(19)17(20)18-16-13(2)8-7-9-14(16)3;;/h7-9,15H,4-6,10-12H2,1-3H3,(H,18,20);1H;1H2/t15-;;/m0../s1
InChI key
VSHFRHVKMYGBJL-CKUXDGONSA-N
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一般描述
罗哌卡因具有一种带有叔胺侧链的利多卡因相关结构。它是一种在哌啶氮原子上带有丙基的纯S(-)对映体。
应用
盐酸罗哌卡因一水合物已被用作串联质谱中的分析物，并作为酰胺基局部麻醉剂以测试其对乳腺癌细胞甲基化的影响。
生化/生理作用
与布比卡因相比，罗哌卡因的亲脂性较低。它可在肝脏中被细胞色素P4501A2酶所代谢。罗哌卡因所引起的中枢神经系统（CNS）毒性较小，可在术后和分娩疼痛期间用作局部麻醉剂。
比布比卡因的心脏毒性小的局部麻醉剂。
比布比卡因的心脏毒性小的局部麻醉剂；通过阻止钠离子通过神经纤维的细胞膜向内运动，可引起沿神经纤维的脉冲传播的可逆性阻断。
特点和优势
该化合物由 AstraZeneca 开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。
警示用语：
Danger
危险声明
危险分类
Eye Dam. 1
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Yuzhuo Wang et al.
International journal of cancer, 142(8), 1602-1610 (2017-12-02)
Traditional pathway analysis map single nucleotide polymorphisms (SNPs) to genes according to physical position, which lacks sufficient biological bases. Here, we incorporated genetics of gene expression into gene- and pathway-based analysis to identify genes and pathways associated with lung cancer
Jian Zhang et al.
Scientific reports, 8(1), 14181-14181 (2018-09-23)
The purpose of this study is to explore Dvl3 variants and their interaction with negative life events on MDD susceptibility in a Chinese Han population. Additionally, we also attempted to identify whether there is an association between Dvl3 variants and
Janson J White et al.
American journal of human genetics, 98(3), 553-561 (2016-03-01)
Robinow syndrome is a rare congenital disorder characterized by mesomelic limb shortening, genital hypoplasia, and distinctive facial features. Recent reports have identified, in individuals with dominant Robinow syndrome, a specific type of variant characterized by being uniformly located in the
P Lirk et al.
British journal of anaesthesia, 113 Suppl 1, i32-i38 (2014-06-21)
Lidocaine demethylates deoxyribonucleic acid (DNA) in breast cancer cells. This modification of epigenetic information may be of therapeutic relevance in the perioperative period, because a decrease in methylation can reactivate tumour suppressor genes and inhibit tumour growth. The objectives of
Gaurav Kuthiala et al.
Indian journal of anaesthesia, 55(2), 104-110 (2011-06-30)
Ropivacaine is a long-acting amide local anaesthetic agent and first produced as a pure enantiomer. It produces effects similar to other local anaesthetics via reversible inhibition of sodium ion influx in nerve fibres. Ropivacaine is less lipophilic than bupivacaine and
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