所有图片(1)
别名:
(2S)-N-(2,6-二甲基苯基)-1-丙基-2-哌啶甲酰胺 盐酸盐 一水合物, (S)-N-(2,6-二甲基苯基)-1-丙基哌啶-2-羧酰胺 盐酸盐 一水合物, 那洛平 盐酸盐 一水合物
经验公式（希尔记法）:
C17H26N2O · HCl · H2O
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质量水平
检测方案
≥98% (HPLC)
形式
powder
旋光性
[α]/D -9 to -12, c = 1 in methanol
储存条件
desiccated
颜色
white to off-white
溶解性
H2O: 5 mg/mL, clear
创始人
AstraZeneca
储存温度
2-8°C
SMILES字符串
O.Cl.CCCN1CCCC[C@H]1C(=O)Nc2c(C)cccc2C
InChI
1S/C17H26N2O.ClH.H2O/c1-4-11-19-12-6-5-10-15(19)17(20)18-16-13(2)8-7-9-14(16)3;;/h7-9,15H,4-6,10-12H2,1-3H3,(H,18,20);1H;1H2/t15-;;/m0../s1
InChI key
VSHFRHVKMYGBJL-CKUXDGONSA-N
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一般描述
罗哌卡因具有一种带有叔胺侧链的利多卡因相关结构。它是一种在哌啶氮原子上带有丙基的纯S(-)对映体。
应用
盐酸罗哌卡因一水合物已被用作串联质谱中的分析物，并作为酰胺基局部麻醉剂以测试其对乳腺癌细胞甲基化的影响。
生化/生理作用
与布比卡因相比，罗哌卡因的亲脂性较低。它可在肝脏中被细胞色素P4501A2酶所代谢。罗哌卡因所引起的中枢神经系统（CNS）毒性较小，可在术后和分娩疼痛期间用作局部麻醉剂。
比布比卡因的心脏毒性小的局部麻醉剂；通过阻止钠离子通过神经纤维的细胞膜向内运动，可引起沿神经纤维的脉冲传播的可逆性阻断。
特点和优势
该化合物由 AstraZeneca 开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。
警示用语：
Danger
危险声明
危险分类
Eye Dam. 1
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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