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Merck
CN

Q3638

喹硫平 半富马酸盐

≥98% (HPLC), serotonin (5HT2) and dopamine (D2) receptor antagonist, powder

别名:

2-[2-（4-二苯并[b，f] [1,4]硫氮杂-11-基-1-哌嗪基）乙氧基]乙醇半富马酸盐, 喹硫平富马酸盐

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关于此项目

经验公式（希尔记法）:
C21H25N3O2S · 0.5C4H4O4
化学文摘社编号:
111974-72-2
分子量:
441.54
UNSPSC Code:
12352200
PubChem Substance ID:
329823864
NACRES:
NA.77
MDL number:
MFCD03423782

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产品名称

喹硫平 半富马酸盐, ≥98% (HPLC)

SMILES string

OC(=O)\C=C\C(O)=O.OCCOCCN1CCN(CC1)C2=Nc3ccccc3Sc4ccccc24.OCCOCCN5CCN(CC5)C6=Nc7ccccc7Sc8ccccc68

InChI key

ZTHJULTYCAQOIJ-WXXKFALUSA-N

InChI

1S/2C21H25N3O2S.C4H4O4/c2*25-14-16-26-15-13-23-9-11-24(12-10-23)21-17-5-1-3-7-19(17)27-20-8-4-2-6-18(20)22-21;5-3(6)1-2-4(7)8/h2*1-8,25H,9-16H2;1-2H,(H,5,6)(H,7,8)/b;;2-1+

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to off-white

solubility

DMSO: >10 mg/mL

originator

AstraZeneca

storage temp.

2-8°C

Quality Level

100

Gene Information

human ... DRD2(1813), HTR2A(3356), HTR2C(3358)

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Features and Benefits

该化合物由AstraZeneca开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。
《受体分类和信号转导》手册的多巴胺受体页有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。

General description

喹硫平是一种二苯并硫氮杂卓衍生物，也称为舍罗库尔和氯马斯汀。

Application

喹硫平半富马酸盐已被用作β-抑制蛋白2 突变体T205M 募集的拮抗剂。

Biochem/physiol Actions

喹硫平促进少突胶质细胞的体外形成。它用于治疗抑郁症。
喹硫平半富马酸盐是一种联合血清素（5HT2）和多巴胺（D2）受体拮抗剂。
喹硫平半富马酸盐是一种非典型抗精神病药，一种联合血清素（5HT2）和多巴胺（D2）受体拮抗剂。

pictograms

Exclamation markEnvironment
GHS07,GHS09

signalword

Warning

hcodes

H302,H400

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000233389
0000233389
0000414432
0000414432
0000017823

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Meng He et al.
Frontiers in aging neuroscience, 14, 847561-847561 (2022-05-27)
Emerging data indicate that antipsychotic treatment causes brain volume loss and astrocyte death, but the mechanisms remain elusive. Pyroptosis, inflammatory cell death characterized by the formation of inflammatory bodies, increased expression of nod-like receptor proteins (NLRPs) such as NLRP3, and
Preparation of rat oligodendrocyte progenitor cultures and quantification of oligodendrogenesis using dual-infrared fluorescence scanning
Schott JT, et al.
Journal of Visualized Experiments, 108, e53764-e53764 (2016)
Ying-Ying He et al.
Peptides, 29(10), 1692-1699 (2008-06-28)
Snake venom Kunitz/BPTI members are good tools for understanding of structure-functional relationship between serine proteases and their inhibitors. A novel dual Kunitz/BPTI serine proteinase inhibitor named OH-TCI (trypsin- and chymotrypsin-dual inhibitor from Ophiophagus hannah) was isolated from king cobra venom
Jason T Schott et al.
Journal of visualized experiments : JoVE, (108), 53764-53764 (2016-03-12)
Efficient oligodendrogenesis is the therapeutic goal of a number of areas of research including spinal cord injury, neonatal hypoxia, and demyelinating diseases such as multiple sclerosis and transverse myelitis. Myelination is required to not only facilitate rapid impulse propagation within
Marc F Goldstein et al.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 97(6), 717-730 (2007-01-05)
To review and compare previously reported cases of selective IgM immunodeficiency (SIgMID) with the largest adult cohort obtained from a retrospective analysis of an allergy and immunology practice. Publications were selected from the English-only PubMed database (1966-2005) using the following
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