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Q3251

Sigma-Aldrich

喹吖因 二盐酸盐

≥90% (TLC), powder, MAO-A/B inhibitor

别名:

6-氯-9-(4-二乙氨基-1-甲基丁氨基)-2-甲氧基吖啶 二盐酸盐, 米帕林 二盐酸盐, 阿的平 二盐酸盐

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About This Item

经验公式（希尔记法）:
C23H30ClN3O · 2HCl
CAS号:
69-05-6
分子量:
472.88
Beilstein:
4834013
EC 号:
200-700-8
MDL编号:
MFCD00012659
UNSPSC代码:
12352101
PubChem化学物质编号:
24278192
NACRES:
NA.77

产品名称

喹吖因 二盐酸盐, ≥90%

生物来源

synthetic

质量水平

100

方案

≥90%

表单

powder

mp

257 °C

溶解性

H2O: soluble, clear to hazy

创始人

Bayer

SMILES字符串

Cl[H].Cl[H].CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc3ccc(OC)cc13

InChI

1S/C23H30ClN3O.2ClH/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23;;/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26);2*1H

InChI key

UDKVBVICMUEIKS-UHFFFAOYSA-N

基因信息

human ... MAOA(4128) , MAOB(4129)

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一般描述

阿的平是吖啶衍生物，是一种强效抗疟药。

应用

二盐酸奎纳克林已用于：
  • 在荧光显微镜下研究其在小鼠肺切片中的摄取和蓄积
  • 在间充质干细胞 (MSCs) ATP 囊泡染色中的应用
  • 在摄取-释放试验中用于表征血小板致密颗粒功能性

生化/生理作用

阿的平具有驱虫作用，用于女性绝育。用于治疗系统性红斑狼疮及风湿性疾病。除疟疾外，阿的平对治疗贾第虫和绦虫感染有效。除抑制单胺氧化酶外，还能抑制烟酰胺腺嘌呤二核苷酸磷酸 (NADPH) 氧化酶活性。
非选择性 MAO-A/B 抑制剂。

特点和优势

该化合物由 Bayer 开发。如需浏览其他制药公司开发的化合物和批准的药物/候选药物列表，请点击此处。

储存及稳定性

Stock solutions are stable for up to 60 h at 20°C.

其他说明

This product is not assigned an expiration date or recommended retest date.

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302

危险分类

Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCJ4898
BCCG8201
BCCD8591
BCCB2922
BCBV6879

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. Can Product Q3251, Quinacrine dihydrochloride be used for staining platelets?

    We have not tested Product Q3251, Quinacrine dihydrochloride for staining platelets. The reference link indicates that platelets can be visualized with the fluorescent dye mepacrine (quinacrine dihydrochloride) at a final concentration of 10 μM.  Brian Savage, et al., PNAS, 99 (1): 425-430, (2002).

  6. My question is not addressed here, how can I contact Technical Service for assistance?

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