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Q2876

Sigma-Aldrich

喹吖因氮芥 二盐酸盐

≥85% (HPLC)

别名:

氮芥喹丫因 二盐酸盐, 氮芥喹丫因 二盐酸盐 二盐酸盐

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About This Item

经验公式（希尔记法）:
C23H28Cl3N3O · 2HCl
CAS号:
4213-45-0
分子量:
541.77
Beilstein:
3819822
EC 号:
224-140-9
MDL编号:
MFCD00043254
UNSPSC代码:
12352101
PubChem化学物质编号:
24899329
NACRES:
NA.32

质量水平

200

方案

≥85% (HPLC)

储存温度

−20°C

SMILES字符串

Cl[H].Cl[H].COc1ccc2nc3cc(Cl)ccc3c(NC(C)CCCN(CCCl)CCCl)c2c1

InChI

1S/C23H28Cl3N3O.2ClH/c1-16(4-3-11-29(12-9-24)13-10-25)27-23-19-7-5-17(26)14-22(19)28-21-8-6-18(30-2)15-20(21)23;;/h5-8,14-16H,3-4,9-13H2,1-2H3,(H,27,28);2*1H

InChI key

JETDZFFCRPFPDH-UHFFFAOYSA-N

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一般描述

氮芥喹丫因（Quinacrine mustard dihydrochloride） 是一种荧光吖啶染料，简称QM。在水溶液中，氯乙基迅速失去氯离子，产生氮丙啶阳离子。这些阳离子很容易与蛋白质和核酸的羧基、硫醇和杂环氮基团或其他亲核试剂发生反应。

应用

氮芥喹丫因（Quinacrine mustard dihydrochloride）用于染色中期染色体。最新应用包括玉米的 Q 带分析和鱼类的核型分析。该染料还用作锥虫的活体染色剂。

象形图

Skull and crossbonesHealth hazard
GHS06,GHS08

警示用语：

Danger

危险分类

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Repr. 2 - Resp. Sens. 1 - Skin Sens. 1

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
WXBD3811V
SLCD2226
SLCB7796
SLBX8180
SLBT9169

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. Is quinacrine mustard, product Q2876, suitable as a viability stain for platelets?

    A customer's feedback utlizing the method outlined in Moroi, M. et al., Blood, 88(6), 2081-2092 (1996), stated it performed pretty well, giving a strong green signal using a standard GFP-filter.

  6. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

J A Hartley et al.
Nucleic acids research, 20(12), 3175-3178 (1992-06-25)
Nitrogen mustard alkylating agents react with isolated DNA in a sequence selective manner, and the substituent attached to the drug reactive group can impose a distinct sequence preference. It is not clear however to what extent the observed DNA sequence
S Fabbri et al.
Carcinogenesis, 14(9), 1963-1967 (1993-09-01)
Nitrogen mustard (HN2) and quinacrine mustard (QM) both inhibited the binding of NF kappa B to the GC-rich consensus sequence in the HIV long terminal repeat (LTR), as assessed by gel-shift assays. QM also inhibited the binding of OTF-1 to
W B Mattes
Analytical biochemistry, 206(1), 161-167 (1992-10-01)
Alkylation at the N7 position of guanine in DNA renders the C8-hydrogen acidic. This serves as the basis for an assay of guanine N7 alkylation using [8-3H]-guanine-labeled DNA. I modified the assay by preparing a high specific activity substrate in
Michiko Inuma et al.
Zoological science, 26(5), 344-348 (2009-09-01)
Chromosomes stained with fluorochromes, including quinacrine mustard (QM), emit the brightest fluorescence immediately after exposure to excitation light, and the fluorescence gradually fades with an increase in exposure time. However, in the QM-stained chromosomes of the small Japanese field mouse
M L Check et al.
Archives of andrology, 44(1), 47-50 (2000-02-26)
Previous methods of enriching sperm with a higher percentage of Y-bearing sperm have been questioned because the claims that Y enrichment was present were based on quinacrine staining of the Y chromosome, and the enrichment was not confirmed by polymerase
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