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重组
expressed in E. coli
质量水平
方案
≥90% (SDS-PAGE)
表单
lyophilized powder (one vial contains one mg protein)
比活
≥100 units/mg protein
UniProt登记号
储存温度
−20°C
基因信息
human ... NQO2(4835)
应用
Quinone oxidoreductase 2 has been used in a study to investigate whether recent advances in limiting paraquat′s toxicity makes it safer for use as an herbicide. Quinone oxidoreductase 2 has also been used in a study to investigate the NQO2-mediated toxicity of the chemotherapeutic drug CB1954.
The product from Sigma has been used to identify novel inhibitors of the enzyme NQO2. It has also been used to investigate the effect of afobazole on quinone reductase 2 activity.
生化/生理作用
Modulation of NQO2 activity can have effects on the levels and functions of the tumour suppressor, p53. Deletion of NQO2 can alter intra-cellular signalling via the NF-κB pathway.
Unique human oxidoreductase that uses Dihydronicotinamide riboside (NRH) as a cosubstrate, not NAD(P)H. Activates anticancer prodrugs. Putative melatonin receptor.
单位定义
One unit will catalyze the oxidation of one micromole of 1-methyl-1,4-dihydronicotinamide to 1-methylnicotinamide per minute in the presence of menadione at pH 7.4 at 37 °C.
外形
contains 10% PBS buffer salts
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
Paraquat Research. Do Recent Advances In Limiting Its Toxicity Make Its Use Safer?
Baltazar, T., et al.
British Journal of Pharmacology (2012)
Effect of Afobazole on Activity of Quinone Reductase 2
Kadnikov IA, et al.
Pharmaceutical Chemistry Journal, 47(10), 514-516 (2014)
Karen A Nolan et al.
Molecular cancer therapeutics, 11(1), 194-203 (2011-11-18)
The National Cancer Institute chemical database has been screened using in silico docking to identify novel nanomolar inhibitors of NRH:quinone oxidoreductase 2 (NQO2). The inhibitors identified from the screen exhibit a diverse range of scaffolds and the structure of one
Qiuying Cheng et al.
Biochemical pharmacology, 83(1), 139-148 (2011-10-18)
Carbonyl reductase activity catalyzes the two electron reduction of several endogenous and exogenous carbonyl substrates. Recent data indicate that the expression of human carbonyl reductase 3 (CBR3) is regulated by the master redox switch Nrf2. Nrf2 binds to conserved antioxidant
Faisal Hayat et al.
International journal of molecular sciences, 22(3) (2021-01-28)
As catabolites of nicotinamide possess physiological relevance, pyridones are often included in metabolomics measurements and associated with pathological outcomes in acute kidney injury (AKI). Pyridones are oxidation products of nicotinamide, its methylated form, and its ribosylated form. While they are
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