推荐产品
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
room temp
SMILES字符串
NC(C1(CCOCC1)C2=CC=CC(SC3=CC=C(C4=CC=NN4C)C=C3)=C2)=O
InChI
1S/C22H23N3O2S/c1-25-20(9-12-24-25)16-5-7-18(8-6-16)28-19-4-2-3-17(15-19)22(21(23)26)10-13-27-14-11-22/h2-9,12,15H,10-11,13-14H2,1H3,(H2,23,26)
InChI key
DVNQWYLVSNPCJZ-UHFFFAOYSA-N
生化/生理作用
PF-4191834 a selective, non-redox, non-iron chelating competitive inhibitor of 5-lipoxygenase effective in inflammation and pain.
PF-4191834 is known to reduce the indications of arthritis.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
从最新的版本中选择一种：
Jaime L Masferrer et al.
The Journal of pharmacology and experimental therapeutics, 334(1), 294-301 (2010-04-10)
5-Lipoxygenase (LOX) is an important arachidonic acid-metabolizing enzyme producing leukotrienes and other proinflammatory lipid mediators with potent pathophysiological functions in asthma and other inflammatory diseases. 4-(3-(4-(1-Methyl-1H-pyrazol-5-yl)phenylthio)phenyl)-tetrahydro-2H-pyran-4-carboxamide (PF-4191834) is a novel, selective non-redox 5-lipoxygenase inhibitor effective in inflammation and pain. In
Han-Ching Lin et al.
PloS one, 9(9), e107890-e107890 (2014-09-18)
The lipoxygenase isoform of 5-lipoxygenase (5-LOX) is reported to be overexpressed in human rheumatoid arthritis synovial tissue and involved in the progress of inflammatory arthritis. However, the detailed mechanism of how 5-lipoxygenase regulates the inflammatory response in arthritis synovial tissue
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