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质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 5 mg/mL, clear (warmed)
储存温度
room temp
SMILES字符串
FC1(F)C[C@H]1C(N2[C@H]3CN(C4=CC=NC(NC5=CN(C)N=C5)=N4)C[C@@H]2CC3)=O.CC6=CC=C(S(=O)(O)=O)C=C6
InChI key
FAKGOYNHHHOTEN-VDTKTRGNSA-N
应用
PF-06700841甲苯磺酸盐已作为Janus激酶1抑制剂，研究其对佐剂诱导型关节炎(AIA)大鼠模型的治疗作用。它也用作小鼠中干扰素-α/β受体α链(IFNAR1)信号转导接头蛋白酪氨酸激酶(2TYK2)的抑制剂。
生化/生理作用
PF-06700841是一种JAK1和TYK2激酶抑制剂。已经研究了PF-06700841用于治疗牛皮癣和狼疮。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
308 Bone marrow/cord blood transplantation (BMCBT) ameliorates symptoms in some, but not all, subtypes of severe generalized junctional epidermolysis bullosa (JEB).
Hook K, et al.
The Journal of Investigative Dermatology, 137(5), S52-S52 (2017)
Andrew Fensome et al.
Journal of medicinal chemistry, 61(19), 8597-8612 (2018-08-17)
Cytokine signaling is an important characteristic of autoimmune diseases. Many pro-inflammatory cytokines signal through the Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) pathway. JAK1 is important for the γ-common chain cytokines, interleukin (IL)-6, and type-I interferon (IFN) family
Christopher R Donnelly et al.
Nature, 591(7849), 275-280 (2021-01-15)
The innate immune regulator STING is a critical sensor of self- and pathogen-derived DNA. DNA sensing by STING leads to the induction of type-I interferons (IFN-I) and other cytokines, which promote immune-cell-mediated eradication of pathogens and neoplastic cells1,2. STING is
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