质量水平
检测方案
≥98% (HPLC)
形式
powder
储存条件
desiccated
颜色
white to beige
溶解性
DMSO: 5 mg/mL, clear (warmed)
运输
dry ice
储存温度
−20°C
InChI
1S/C17H18ClN5O2.ClH/c18-11-2-1-3-13(8-11)25-9-14-15-16(19)20-10-21-17(15)23(22-14)12-4-6-24-7-5-12;/h1-3,8,10,12H,4-7,9H2,(H2,19,20,21);1H
InChI key
QZXZQMUZEHTFHD-UHFFFAOYSA-N
生化/生理作用
PF-4800567 is a casein kinase 1e (CK1e) selective inhibitor (IC50 = 32 nM) that is 20 fold selective for the CK1e isoform over CK1d. PF-4800567 blockes CK1e-mediated PER3 nuclear translocation, but does not effect the circadian clock in animal studies.
PF-4800567 is also known as (3-[(3-Chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine hydrochloride). It can block the epidermal growth factor receptor (EGFR) at micromolar concentrations. PF-4800567 helps to improve the locomotor stimulant reaction to methamphetamine (MA) and fentanyl.
其他说明
PF-4800567 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the PF-4800567 probe summary on the Chemical Probes Portal website.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Csnk1e is a genetic regulator of sensitivity to psychostimulants and opioids
Bryant, et al.
Neuropsychopharmacology, 37(4), 1026-1026 (2012)
Combined Pharmacological and Genetic Manipulations Unlock Unprecedented Temporal Elasticity and Reveal Phase-Specific Modulation of the Molecular Circadian Clock of the Mouse Suprachiasmatic Nucleus.
Patton AP, et al.
The Journal of Neuroscience, 36(36), 9326-9341 (2016)
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